2voj

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[[Image:2voj.jpg|left|200px]]
 
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{{Structure
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==Ternary complex of M. tuberculosis Rv2780 with NAD and pyruvate==
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|PDB= 2voj |SIZE=350|CAPTION= <scene name='initialview01'>2voj</scene>, resolution 2.60&Aring;
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<StructureSection load='2voj' size='340' side='right'caption='[[2voj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Binding+Site+For+Residue+Nad+A+500'>AC1</scene>, <scene name='pdbsite=AC2:Binding+Site+For+Residue+2op+A+501'>AC2</scene>, <scene name='pdbsite=AC3:Binding+Site+For+Residue+Nad+C+500'>AC3</scene>, <scene name='pdbsite=AC4:Binding+Site+For+Residue+2op+C+501'>AC4</scene>, <scene name='pdbsite=AC5:Binding+Site+For+Residue+Nad+E+500'>AC5</scene> and <scene name='pdbsite=AC6:Binding+Site+For+Residue+2op+E+501'>AC6</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene> and <scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC ACID'>2OP</scene>
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<table><tr><td colspan='2'>[[2voj]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VOJ FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Alanine_dehydrogenase Alanine dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.1.1 1.4.1.1]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2OP:(2S)-2-HYDROXYPROPANOIC+ACID'>2OP</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2voj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2voj OCA], [https://pdbe.org/2voj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2voj RCSB], [https://www.ebi.ac.uk/pdbsum/2voj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2voj ProSAT]</span></td></tr>
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</table>
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'''TERNARY COMPLEX OF M. TUBERCULOSIS RV2780 WITH NAD AND PYRUVATE'''
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== Function ==
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[https://www.uniprot.org/uniprot/DHA_MYCTU DHA_MYCTU] Catalyzes the reversible reductive amination of pyruvate to L-alanine. However, since the physiological environment of M.tuberculosis has a neutral pH, it can be assumed that the enzyme catalyzes exclusively the formation of L-alanine. May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer.<ref>PMID:10527947</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2VOJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VOJ OCA].
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Check<jmol>
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[[Category: Alanine dehydrogenase]]
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vo/2voj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2voj ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Single protein]]
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[[Category: Ramachandran R]]
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[[Category: Ramachandran, R.]]
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[[Category: Tripathi SM]]
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[[Category: Tripathi, S M.]]
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[[Category: 2OP]]
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[[Category: NAD]]
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[[Category: alanine dehydrogenase]]
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[[Category: nad]]
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[[Category: oxidoreductase]]
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[[Category: pyruvate]]
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[[Category: rv2780]]
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[[Category: secreted]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:47:56 2008''
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Current revision

Ternary complex of M. tuberculosis Rv2780 with NAD and pyruvate

PDB ID 2voj

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