2vpi

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (15:27, 13 December 2023) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2vpi.jpg|left|200px]]
 
-
{{Structure
+
==Human GMP synthetase - glutaminase domain==
-
|PDB= 2vpi |SIZE=350|CAPTION= <scene name='initialview01'>2vpi</scene>, resolution 2.40&Aring;
+
<StructureSection load='2vpi' size='340' side='right'caption='[[2vpi]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[2vpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VPI FirstGlance]. <br>
-
|ACTIVITY= [http://en.wikipedia.org/wiki/GMP_synthase_(glutamine-hydrolyzing) GMP synthase (glutamine-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.5.2 6.3.5.2]
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpi OCA], [https://pdbe.org/2vpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vpi RCSB], [https://www.ebi.ac.uk/pdbsum/2vpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vpi ProSAT]</span></td></tr>
-
}}
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/GUAA_HUMAN GUAA_HUMAN] A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with KMT2A/MLL1.
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/GUAA_HUMAN GUAA_HUMAN] Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.<ref>PMID:8089153</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vpi_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vpi ConSurf].
 +
<div style="clear:both"></div>
-
'''HUMAN GMP SYNTHETASE- GLUTAMINASE DOMAIN'''
+
==See Also==
-
 
+
*[[GMP synthase|GMP synthase]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2VPI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VPI OCA].
+
__TOC__
-
[[Category: GMP synthase (glutamine-hydrolyzing)]]
+
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Berg, S Van Den.]]
+
[[Category: Berglund H]]
-
[[Category: Berglund, H.]]
+
[[Category: Busam RD]]
-
[[Category: Busam, R D.]]
+
[[Category: Collins R]]
-
[[Category: Collins, R.]]
+
[[Category: Dahlgren LG]]
-
[[Category: Dahlgren, L G.]]
+
[[Category: Edwards AM]]
-
[[Category: Edwards, A M.]]
+
[[Category: Flodin S]]
-
[[Category: Flodin, S.]]
+
[[Category: Flores A]]
-
[[Category: Flores, A.]]
+
[[Category: Graslund S]]
-
[[Category: Graslund, S.]]
+
[[Category: Hammarstrom M]]
-
[[Category: Hammarstrom, M.]]
+
[[Category: Herman MD]]
-
[[Category: Herman, M D.]]
+
[[Category: Johansson I]]
-
[[Category: Johansson, I.]]
+
[[Category: Kallas A]]
-
[[Category: Kallas, A.]]
+
[[Category: Karlberg T]]
-
[[Category: Karlberg, T.]]
+
[[Category: Kotenyova T]]
-
[[Category: Kotenyova, T.]]
+
[[Category: Lehtio L]]
-
[[Category: Lehtio, L.]]
+
[[Category: Moche M]]
-
[[Category: Moche, M.]]
+
[[Category: Nilsson ME]]
-
[[Category: Nilsson, M E.]]
+
[[Category: Nordlund P]]
-
[[Category: Nordlund, P.]]
+
[[Category: Nyman T]]
-
[[Category: Nyman, T.]]
+
[[Category: Persson C]]
-
[[Category: Persson, C.]]
+
[[Category: Sagemark J]]
-
[[Category: Sagemark, J.]]
+
[[Category: Svensson L]]
-
[[Category: Sgc, Structural Genomics Consortium.]]
+
[[Category: Thorsell AG]]
-
[[Category: Svensson, L.]]
+
[[Category: Tresaugues L]]
-
[[Category: Thorsell, A G.]]
+
[[Category: Van Der Berg S]]
-
[[Category: Tresaugues, L.]]
+
[[Category: Weigelt J]]
-
[[Category: Weigelt, J.]]
+
[[Category: Welin M]]
-
[[Category: Welin, M.]]
+
-
[[Category: atp-binding]]
+
-
[[Category: chromosomal rearrangement]]
+
-
[[Category: cytoplasm]]
+
-
[[Category: glutaminase domain]]
+
-
[[Category: glutamine amidotransferase]]
+
-
[[Category: gmp biosynthesis]]
+
-
[[Category: gmp synthetase]]
+
-
[[Category: gmp]]
+
-
[[Category: guanine monophosphate synthetase]]
+
-
[[Category: ligase]]
+
-
[[Category: nucleotide-binding]]
+
-
[[Category: phosphoprotein]]
+
-
[[Category: proto-oncogene]]
+
-
[[Category: purine biosynthesis]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:48:02 2008''
+

Current revision

Human GMP synthetase - glutaminase domain

PDB ID 2vpi

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vpi"
Personal tools