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4r11

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==A conserved phosphorylation switch controls the interaction between cadherin and beta-catenin in vitro and in vivo==
==A conserved phosphorylation switch controls the interaction between cadherin and beta-catenin in vitro and in vivo==
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<StructureSection load='4r11' size='340' side='right' caption='[[4r11]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
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<StructureSection load='4r11' size='340' side='right'caption='[[4r11]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4r11]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R11 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R11 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4r11]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R11 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R11 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r11 OCA], [https://pdbe.org/4r11 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r11 RCSB], [https://www.ebi.ac.uk/pdbsum/4r11 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r11 ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r0z|4r0z]], [[4r10|4r10]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r11 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r11 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r11 RCSB], [http://www.ebi.ac.uk/pdbsum/4r11 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HMP2_CAEEL HMP2_CAEEL]] Required for cell migration during body enclosure and cell shape changes during body elongation.<ref>PMID:9531567</ref> [[http://www.uniprot.org/uniprot/HMR1_CAEEL HMR1_CAEEL]] Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Isoform A is required for cell migration during body enclosure and cell shape changes during body elongation. Required for proper localization of other junctional components, such as hmp-1, hmp-2 and jac-1. Isoform b is involved in axonal guidance in a subset of motor neurons.<ref>PMID:11790304</ref> <ref>PMID:12847081</ref> <ref>PMID:9531567</ref>
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[https://www.uniprot.org/uniprot/HMP2_CAEEL HMP2_CAEEL] Required for cell migration during body enclosure and cell shape changes during body elongation.<ref>PMID:9531567</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4r11" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bang, I]]
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[[Category: Caenorhabditis elegans]]
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[[Category: Choi, H J]]
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[[Category: Large Structures]]
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[[Category: Hardin, J]]
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[[Category: Bang I]]
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[[Category: Loveless, T]]
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[[Category: Choi H-J]]
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[[Category: Lynch, A]]
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[[Category: Hardin J]]
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[[Category: Weis, W I]]
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[[Category: Loveless T]]
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[[Category: Armadillo repeat]]
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[[Category: Lynch A]]
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[[Category: Cell adhesion]]
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[[Category: Weis WI]]
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[[Category: Cell adhesion-protein binding complex]]
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[[Category: Phosphorylation]]
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Current revision

A conserved phosphorylation switch controls the interaction between cadherin and beta-catenin in vitro and in vivo

PDB ID 4r11

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