2n1w
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2n1w is ON HOLD Authors: Naik, M.T., Naik, N., Shih, H., Huang, T. Description: Solution structure of human SUMO2 [[Category: Unreleased Structures...) |
|||
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of human SUMO2== | |
| + | <StructureSection load='2n1w' size='340' side='right'caption='[[2n1w]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2n1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N1W FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n1w OCA], [https://pdbe.org/2n1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n1w RCSB], [https://www.ebi.ac.uk/pdbsum/2n1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n1w ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SUMO2_HUMAN SUMO2_HUMAN] Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins.<ref>PMID:9556629</ref> <ref>PMID:18538659</ref> <ref>PMID:18408734</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[SUMO 3D Structures|SUMO 3D Structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Huang | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Naik | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Huang T]] | ||
| + | [[Category: Naik MT]] | ||
| + | [[Category: Naik N]] | ||
| + | [[Category: Shih H]] | ||
Current revision
Solution structure of human SUMO2
| |||||||||||
Categories: Homo sapiens | Large Structures | Huang T | Naik MT | Naik N | Shih H
