2n26
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2n26 is ON HOLD Authors: Bedard, M., Lavigne, P. Description: Solution structure of Miz-1 zinc fingers 3 and 4 Category: Unreleased Structures ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of Miz-1 zinc fingers 3 and 4== | |
| - | + | <StructureSection load='2n26' size='340' side='right'caption='[[2n26]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2n26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N26 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: Bedard | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n26 OCA], [https://pdbe.org/2n26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n26 RCSB], [https://www.ebi.ac.uk/pdbsum/2n26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n26 ProSAT]</span></td></tr> |
| - | [[Category: Lavigne | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZBT17_HUMAN ZBT17_HUMAN] Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment (By similarity). Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation.<ref>PMID:9312026</ref> <ref>PMID:9308237</ref> <ref>PMID:19164764</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bedard M]] | ||
| + | [[Category: Lavigne P]] | ||
Current revision
Solution structure of Miz-1 zinc fingers 3 and 4
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