4zhn

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m (Protected "4zhn" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 4zhn is ON HOLD
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==Crystal Structure of AlkB T208A mutant protein in complex with Co(II), 2-oxoglutarate, and methylated trinucleotide T-meA-T==
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<StructureSection load='4zhn' size='340' side='right'caption='[[4zhn]], [[Resolution|resolution]] 1.33&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4zhn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZHN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.333&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=MA7:1N-METHYLADENOSINE-5-MONOPHOSPHATE'>MA7</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zhn OCA], [https://pdbe.org/4zhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zhn RCSB], [https://www.ebi.ac.uk/pdbsum/4zhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zhn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ALKB_ECOLI ALKB_ECOLI] Dioxygenase that repairs alkylated DNA and RNA containing 3-methylcytosine or 1-methyladenine by oxidative demethylation. Has highest activity towards 3-methylcytosine. Has lower activity towards alkylated DNA containing ethenoadenine, and no detectable activity towards 1-methylguanine or 3-methylthymine. Accepts double-stranded and single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Provides extensive resistance to alkylating agents such as MMS and DMS (SN2 agents), but not to MMNG and MNU (SN1 agents).<ref>PMID:12226668</ref> <ref>PMID:12594517</ref> <ref>PMID:16482161</ref> <ref>PMID:19706517</ref> <ref>PMID:21068844</ref> <ref>PMID:20084272</ref>
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Authors: Ergel, B., Yu, B., Vorobiev, S.M., Forouhar, F., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
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==See Also==
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Ergel, B]]
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__TOC__
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[[Category: Vorobiev, S.M]]
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</StructureSection>
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[[Category: Yu, B]]
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[[Category: Escherichia coli K-12]]
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[[Category: Northeast Structural Genomics Consortium (Nesg)]]
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[[Category: Large Structures]]
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[[Category: Forouhar, F]]
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[[Category: Synthetic construct]]
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[[Category: Hunt, J.F]]
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[[Category: Ergel B]]
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[[Category: Forouhar F]]
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[[Category: Hunt JF]]
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[[Category: Vorobiev SM]]
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[[Category: Yu B]]

Current revision

Crystal Structure of AlkB T208A mutant protein in complex with Co(II), 2-oxoglutarate, and methylated trinucleotide T-meA-T

PDB ID 4zhn

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