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2yxe

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[[Image:2yxe.gif|left|200px]]
 
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{{Structure
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==Crystal structure of L-isoaspartyl protein carboxyl methyltranferase==
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|PDB= 2yxe |SIZE=350|CAPTION= <scene name='initialview01'>2yxe</scene>, resolution 2.00&Aring;
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<StructureSection load='2yxe' size='340' side='right'caption='[[2yxe]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACT:ACETATE ION'>ACT</scene>
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<table><tr><td colspan='2'>[[2yxe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YXE FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Protein-L-isoaspartate(D-aspartate)_O-methyltransferase Protein-L-isoaspartate(D-aspartate) O-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.77 2.1.1.77]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE= pcm ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2190 Methanocaldococcus jannaschii])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yxe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yxe OCA], [https://pdbe.org/2yxe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yxe RCSB], [https://www.ebi.ac.uk/pdbsum/2yxe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yxe ProSAT], [https://www.topsan.org/Proteins/RSGI/2yxe TOPSAN]</span></td></tr>
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</table>
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'''Crystal structure of L-isoaspartyl protein carboxyl methyltranferase'''
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== Function ==
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[https://www.uniprot.org/uniprot/PIMT_METJA PIMT_METJA] Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins (By similarity).
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2YXE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii Methanocaldococcus jannaschii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YXE OCA].
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Check<jmol>
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[[Category: Methanocaldococcus jannaschii]]
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<jmolCheckbox>
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[[Category: Protein-L-isoaspartate(D-aspartate) O-methyltransferase]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yx/2yxe_consurf.spt"</scriptWhenChecked>
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[[Category: Single protein]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Bessho, Y.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Padmanabhan, B.]]
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</jmolCheckbox>
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2yxe ConSurf].
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[[Category: Yokoyama, S.]]
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<div style="clear:both"></div>
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[[Category: ACT]]
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__TOC__
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[[Category: alpha/beta/alpha sandwich structure]]
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</StructureSection>
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[[Category: national project on protein structural and functional analyse]]
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[[Category: Large Structures]]
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[[Category: nppsfa]]
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[[Category: Methanocaldococcus jannaschii DSM 2661]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: Bessho Y]]
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[[Category: rossman-type fold]]
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[[Category: Padmanabhan B]]
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[[Category: rsgi]]
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[[Category: Yokoyama S]]
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[[Category: structural genomic]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:50:04 2008''
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Current revision

Crystal structure of L-isoaspartyl protein carboxyl methyltranferase

PDB ID 2yxe

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