4zeq

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==Crystal Structure of human BFL-1 in complex with tBid BH3 peptide, Northeast Structural Genomics Consortium Target HX9247==
==Crystal Structure of human BFL-1 in complex with tBid BH3 peptide, Northeast Structural Genomics Consortium Target HX9247==
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<StructureSection load='4zeq' size='340' side='right' caption='[[4zeq]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4zeq' size='340' side='right'caption='[[4zeq]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zeq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZEQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zeq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZEQ FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zeq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zeq RCSB], [http://www.ebi.ac.uk/pdbsum/4zeq PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zeq OCA], [https://pdbe.org/4zeq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zeq RCSB], [https://www.ebi.ac.uk/pdbsum/4zeq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zeq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/B2LA1_HUMAN B2LA1_HUMAN]] Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). [[http://www.uniprot.org/uniprot/BID_HUMAN BID_HUMAN]] The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2.<ref>PMID:14583606</ref>
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[https://www.uniprot.org/uniprot/B2LA1_HUMAN B2LA1_HUMAN] Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).
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== References ==
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<references/>
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Guan, R]]
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[[Category: Homo sapiens]]
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[[Category: Mao, L]]
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[[Category: Large Structures]]
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[[Category: Montelione, G T]]
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[[Category: Guan R]]
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[[Category: Structural genomic]]
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[[Category: Mao L]]
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[[Category: Xiao, R]]
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[[Category: Montelione GT]]
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[[Category: Apoptosis]]
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[[Category: Xiao R]]
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[[Category: Bcl-2 family]]
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[[Category: Bh3 only]]
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[[Category: Complex]]
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[[Category: Nesg]]
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[[Category: Psi-biology]]
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Current revision

Crystal Structure of human BFL-1 in complex with tBid BH3 peptide, Northeast Structural Genomics Consortium Target HX9247

PDB ID 4zeq

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