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PDZ and LIM domain protein
From Proteopedia
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<StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''> | <StructureSection load='2pa1' size='350' side='right' caption='Structure of PDZ and LIM domain protein 2 PDZ domain with C-terminal of β-tropomyosin and Cl- ions (PDB entry [[2pa1]])' scene=''> | ||
| - | + | == Function == | |
| - | '''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure. | + | '''PDZ and LIM domain proteins''' (PDLIM) contain PDZ and LIM domains. PDLIM binds α-actinin via its PDZ domain and other proteins via its LIM domain. PDLIM is implicated in cardiac and skeletal muscle structure<ref>PMID:17767364</ref>.<br /> For details on PDLIM see [[Group:MUZIC:ZASP]] and [[Group:MUZIC:Enigma Family]]. |
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| + | *'''PDLIM1''' promotes cell attachment at the cytoskeleton. For details see [[Group:MUZIC:ALP]].<br /> | ||
| + | *'''PDLIM2''' may have a role in bringing proteins to the cytoskeleton.<br /> | ||
| + | *'''PDLIM3''' may have a role in organizing actin filament arrays within muscle cells.<br /> | ||
| + | *'''PDLIM4''' is a Zn+2 ion binding protein.<br /> | ||
| + | *'''PDLIM5''' has important role in heart development by scaffolding PKC to the Z-disk region.<br /> | ||
| + | *'''PDLIM7''' is an adaptor protein localizing the LIM-binding proteins to muscle tissues.<br /> | ||
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| + | == Relevance == | ||
| + | PDLIM2 may contribute to cancer cells migratory capacity. PDLIM5 overexpression promotes the development of heart hypertrophy.<br /> | ||
</StructureSection> | </StructureSection> | ||
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**[[1v5l]] – mPDLIM PDZ domain - NMR<br /> | **[[1v5l]] – mPDLIM PDZ domain - NMR<br /> | ||
**[[1x64]] – mPDLIM LIM domain - NMR<br /> | **[[1x64]] – mPDLIM LIM domain - NMR<br /> | ||
| + | **[[4ydp]] - hPDLIM PDZ domain <br /> | ||
*PDLIM4 | *PDLIM4 | ||
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**[[2q3g]] – hPDLIM PDZ domain + β-tropomysin C terminal <br /> | **[[2q3g]] – hPDLIM PDZ domain + β-tropomysin C terminal <br /> | ||
| + | **[[7rm8]] – hPDLIM PDZ domain + SNX17 peptide - NMR <br /> | ||
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| + | *PDLIM | ||
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| + | **[[1rgw]] – hPDLIM PDZ domain - NMR<br /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D structures of PDZ and LIM domain protein
Updated on 21-August-2023
References
- ↑ te Velthuis AJ, Bagowski CP. PDZ and LIM domain-encoding genes: molecular interactions and their role in development. ScientificWorldJournal. 2007 Sep 1;7:1470-92. PMID:17767364 doi:10.1100/tsw.2007.232
