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4znr
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4znr is ON HOLD Authors: Jia, N., Jiang, Y.L., Cheng, W., Wang, H.W., Zhou, C.Z., Chen, Y. Description: Crystal structure of daniolysin1 complexed ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Dln1 complexed with Man(alpha1-3)Man== | |
| - | + | <StructureSection load='4znr' size='340' side='right'caption='[[4znr]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4znr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZNR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PRD_900112:3alpha-alpha-mannobiose'>PRD_900112</scene></td></tr> |
| - | [[Category: Chen | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4znr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4znr OCA], [https://pdbe.org/4znr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4znr RCSB], [https://www.ebi.ac.uk/pdbsum/4znr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4znr ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/AEP1_DANRE AEP1_DANRE] Pore-forming protein which might play a role in host defense. Exists as an antiparallel dimer in solution. Can also assemble into an octameric pore-like structure spanning the cell membrane. Oligomerization may be triggered by binding of the jacalin-type lectin domain to high-mannose cell-surface proteoglycans, and also requires a low pH environment. In vitro, shows high binding affinity for S.cerevisiae mannan and human HIV virus glycoprotein gp120.<ref>PMID:26711430</ref> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Danio rerio]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen Y]] | ||
| + | [[Category: Cheng W]] | ||
| + | [[Category: Jia N]] | ||
| + | [[Category: Jiang YL]] | ||
| + | [[Category: Wang HW]] | ||
| + | [[Category: Zhou CZ]] | ||
Current revision
Crystal structure of Dln1 complexed with Man(alpha1-3)Man
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Categories: Danio rerio | Large Structures | Chen Y | Cheng W | Jia N | Jiang YL | Wang HW | Zhou CZ
