4yvm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:53, 3 April 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==X-ray structure of Helicobacter pylori CagL-K74==
==X-ray structure of Helicobacter pylori CagL-K74==
-
<StructureSection load='4yvm' size='340' side='right' caption='[[4yvm]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
+
<StructureSection load='4yvm' size='340' side='right'caption='[[4yvm]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4yvm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YVM FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4yvm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori Helicobacter pylori]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YVM FirstGlance]. <br>
-
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yvm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yvm RCSB], [http://www.ebi.ac.uk/pdbsum/4yvm PDBsum]</span></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.791&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yvm OCA], [https://pdbe.org/4yvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yvm RCSB], [https://www.ebi.ac.uk/pdbsum/4yvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yvm ProSAT]</span></td></tr>
</table>
</table>
-
<div style="background-color:#fffaf0;">
+
== Function ==
-
== Publication Abstract from PubMed ==
+
[https://www.uniprot.org/uniprot/Q75XL3_HELPX Q75XL3_HELPX]
-
Helicobacter pylori (Hp) CagL is a component of the type IV secretion system (T4SS) and interacts with integrin in host cells through its flexible RGD domain to translocate CagA. Differences in CagL amino acid polymorphisms between Western and East-Asian Hps are correlated with clinical outcome. CagL of East-Asian clinical Hp isolate K74 (CagL(K74)) contains multiple residue variations upstream of RGD motif and has different integrin binding affinities compared to those of CagL from Western Hp 26695. Here, we report the crystal structure of CagL(K74). The structure displayed a six-helix bundle including two short alpha-helices, and the RGD motif was found in the long rigid alpha2 helix flanked by the conserved protease-sensitive and RGD-helper sequences, as observed in CagL(26695). However, two additional salt bridges were found between the helices compared with the CagL(26695) structure, suggesting that the putative flexible region harboring the RGD motif may be more stable in this CagL variant.
+
-
 
+
-
Crystal structure of CagL from Helicobacter pylori K74 strain.,Choi JM, Choi YH, Sudhanva MS, Devakumar S, Lee KH, Cha JH, Lee SH Biochem Biophys Res Commun. 2015 May 15;460(4):964-70. doi:, 10.1016/j.bbrc.2015.03.135. Epub 2015 Apr 1. PMID:25839651<ref>PMID:25839651</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Cha, J H]]
 
-
[[Category: Choi, J M]]
 
-
[[Category: Choi, Y H]]
 
-
[[Category: Lee, S H]]
 
-
[[Category: Cagl]]
 
[[Category: Helicobacter pylori]]
[[Category: Helicobacter pylori]]
-
[[Category: Protein binding]]
+
[[Category: Large Structures]]
-
[[Category: Rgd domain]]
+
[[Category: Cha JH]]
-
[[Category: T4ss]]
+
[[Category: Choi JM]]
 +
[[Category: Choi YH]]
 +
[[Category: Lee SH]]

Current revision

X-ray structure of Helicobacter pylori CagL-K74

PDB ID 4yvm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4yvm"
Personal tools