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4ui2

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==Crystal structure of the ternary RGMB-BMP2-NEO1 complex==
==Crystal structure of the ternary RGMB-BMP2-NEO1 complex==
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<StructureSection load='4ui2' size='340' side='right' caption='[[4ui2]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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<StructureSection load='4ui2' size='340' side='right'caption='[[4ui2]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ui2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UI2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UI2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ui2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UI2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SRT:S,R+MESO-TARTARIC+ACID'>SRT</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uhy|4uhy]], [[4uhz|4uhz]], [[4ui0|4ui0]], [[4ui1|4ui1]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ui2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ui2 OCA], [https://pdbe.org/4ui2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ui2 RCSB], [https://www.ebi.ac.uk/pdbsum/4ui2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ui2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ui2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ui2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ui2 RCSB], [http://www.ebi.ac.uk/pdbsum/4ui2 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RGMB_HUMAN RGMB_HUMAN]] Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth. [[http://www.uniprot.org/uniprot/NEO1_MOUSE NEO1_MOUSE]] May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues. [[http://www.uniprot.org/uniprot/BMP2_HUMAN BMP2_HUMAN]] Induces cartilage and bone formation.
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[https://www.uniprot.org/uniprot/NEO1_HUMAN NEO1_HUMAN] May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to their differentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4ui2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Bone morphogenetic protein 3D structures|Bone morphogenetic protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bell, C H]]
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[[Category: Homo sapiens]]
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[[Category: Bishop, B]]
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[[Category: Large Structures]]
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[[Category: Elegheert, J]]
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[[Category: Bell CH]]
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[[Category: Healey, E G]]
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[[Category: Bishop B]]
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[[Category: Padilla-Parra, S]]
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[[Category: Elegheert J]]
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[[Category: Siebold, C]]
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[[Category: Healey EG]]
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[[Category: Axon guidance]]
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[[Category: Padilla-Parra S]]
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[[Category: Bone morphogenetic protein pathway]]
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[[Category: Siebold C]]
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[[Category: Cell surface receptor signaling]]
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[[Category: Hemojuvelin]]
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[[Category: Morphogen]]
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[[Category: Neogenin]]
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[[Category: Repulsive guidance molecule]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of the ternary RGMB-BMP2-NEO1 complex

PDB ID 4ui2

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