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4yoo

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==p107 pocket domain in complex with LIN52 P29A peptide==
==p107 pocket domain in complex with LIN52 P29A peptide==
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<StructureSection load='4yoo' size='340' side='right' caption='[[4yoo]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='4yoo' size='340' side='right'caption='[[4yoo]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yoo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YOO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YOO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yoo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YOO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YOO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gux|1gux]], [[4yoz|4yoz]], [[4yos|4yos]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yoo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yoo OCA], [https://pdbe.org/4yoo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yoo RCSB], [https://www.ebi.ac.uk/pdbsum/4yoo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yoo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yoo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yoo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yoo RCSB], [http://www.ebi.ac.uk/pdbsum/4yoo PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RBL1_HUMAN RBL1_HUMAN]] Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
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[https://www.uniprot.org/uniprot/RBL1_HUMAN RBL1_HUMAN] Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4yoo" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Felthousen, J G]]
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[[Category: Homo sapiens]]
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[[Category: Guiley, K Z]]
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[[Category: Large Structures]]
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[[Category: Liban, T J]]
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[[Category: Felthousen JG]]
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[[Category: Litovchick, L]]
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[[Category: Guiley KZ]]
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[[Category: Ramanan, P]]
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[[Category: Liban TJ]]
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[[Category: Rubin, S M]]
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[[Category: Litovchick L]]
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[[Category: Tripathi, S]]
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[[Category: Ramanan P]]
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[[Category: Cyclin box pocket protein transcriptional regulator cell cycle]]
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[[Category: Rubin SM]]
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[[Category: Transcription]]
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[[Category: Tripathi S]]

Current revision

p107 pocket domain in complex with LIN52 P29A peptide

PDB ID 4yoo

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