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Prolactin

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== Function ==
== Function ==
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'''Prolactin''' (PRL) is a hormone which has numerous effects. It enables females to produce milk. PRL provides the body with sexual gratification. PRL promotes neurogenesis in maternal and fetal brains. PRL stimulates cells which are responsible for the formation of myelin coating on axons<ref>PMID:11015620</ref>.
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'''Prolactin''' (PRL) is a hormone which has numerous effects. It enables females to produce milk. PRL provides the body with sexual gratification. PRL promotes neurogenesis in maternal and fetal brains. PRL stimulates cells which are responsible for the formation of myelin coating on axons. See also [[Prolactin (Hebrew)]].
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See also [[Prolactin (Hebrew)]].
== Disease ==
== Disease ==
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PRL has immunomodulatory effect and plays a role in lupus and rheumatoid arthritis<ref>PMID:17465339</ref>
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== Relevance ==
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== Structural highlights ==
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</StructureSection>
</StructureSection>
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== 3D Structures of prolactinin ==
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== 3D Structures of prolactin ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[3ncc]], [[3nce]], [[3ncf]] – hPRL (mutant) + hPRL receptor extracellular domain (mutant)<br />
[[3ncc]], [[3nce]], [[3ncf]] – hPRL (mutant) + hPRL receptor extracellular domain (mutant)<br />
[[3ew3]] – hPRL + rPRL receptor extracellular domain - rat<br />
[[3ew3]] – hPRL + rPRL receptor extracellular domain - rat<br />
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[[4i18]] - hPRL receptor extracellular domain + antibody<br />
 
== References ==
== References ==

Current revision

Human prolactin (grey) complex with prolactin receptor extracellular domain (green), Na+ (purple) and Ca+2 (green) ions (PDB code 3mzg).

Drag the structure with the mouse to rotate

3D Structures of prolactin

Updated on 07-October-2020

1rw5 – hPRL – human - NMR
2q98 – hPRL (mutant)
3mzg, 3npz – hPRL + hPRL receptor extracellular domain
3d48, 3n06, 3n0p, 3ncb – hPRL (mutant) + hPRL receptor extracellular domain
3ncc, 3nce, 3ncf – hPRL (mutant) + hPRL receptor extracellular domain (mutant)
3ew3 – hPRL + rPRL receptor extracellular domain - rat

References

  1. ↑ Freeman ME, Kanyicska B, Lerant A, Nagy G. Prolactin: structure, function, and regulation of secretion. Physiol Rev. 2000 Oct;80(4):1523-631. PMID:11015620
  2. ↑ Chuang E, Molitch ME. Prolactin and autoimmune diseases in humans. Acta Biomed. 2007;78 Suppl 1:255-61. PMID:17465339

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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