B-cell lymphoma protein

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<StructureSection load='1g5m' size='400' side='right' scene='' caption='NMR structure of bcl-2 [[1g5m]]'>
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<StructureSection load='1g5m' size='350' side='right' scene='' caption='NMR structure of bcl-2 [[1g5m]]'>
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[[Image:Bcl-2_3D.jpg|left|200px]] [[Bcl-2]] family are pro-survival proteins. The name is derived from B-cell lymphoma 2.
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[[Image:Bcl-2_3D.jpg|left|200px]]
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'''Bcl-xL''' known as survival protein is the regulator of apoptosis. '''Mcl-1''' is an induced myeloid cell leukemia differentiation protein. '''Bcl-2-L-7''' is called '''Bak''' for Bcl-2 homologous antagonist/killer.
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'''B-cell lymphoma proteins''' (Bcl) family are pro-survival proteins or '''apoptosis regulators'''.
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*'''Bcl-2''' and '''Bcl-xL''' suppress cell death.
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*'''Bak''' or '''Bcl-2-like-7''' or '''Bcl-2 homologous antagonist/killer''' and '''Bax''' or '''Bcl-2-like-4''' promote apoptosis
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*.'''Bcl-xL''' (Bcl-2-like protein 1) known as '''survival protein''' is the regulator of apoptosis.
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*'''Mcl-1''' is an '''induced myeloid cell leukemia differentiation protein'''.
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*'''Bcl-2-like-11''' is called '''Bim'''.
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'''BH3 domain''' is a Bcl-2 homology 3 domain present in Bcl-2 protein family.
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For '''Bcl-6''' see also [[BCL6 (Hebrew)]]
{{Clear}}
{{Clear}}
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[[Image:signal transduction.jpg|left|500px]]
[[Image:signal transduction.jpg|left|500px]]
{{Clear}}
{{Clear}}
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</StructureSection>
 
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==3D structures of Bcl-2==
 
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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==3D structures of B-cell lymphoma proteins==
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[B-cell lymphoma proteins 3D structures]]
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*Bcl-xL
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</StructureSection>
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**[[1maz]], [[1r2d]], [[2b48]] – hBcl-xL – human<br />
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**[[1r2e]], [[1r2g]], [[1r2h]], [[1r2i]], [[3cva]] - hBcl-xL (mutant)<br />
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**[[1lxl]] - hBcl-xL residues 1-209 - NMR<br />
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**[[3pl7]] - hBcl-xL (mutant) + apoptosis regulator BAX BH3 domain<br />
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**[[3fdl]] - hBcl-xL + BH3 peptide<br />
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**[[3fdm]] - hBcl-xL + α/β peptide foldamer<br />
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**[[3inq]] - hBcl-xL (mutant) + inhibitor<br />
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**[[1ysg]] - hBcl-xL + inhibitor<br />
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**[[2w3l]] – hBcl-xL + quinoline derivative<br />
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**[[2o1y]], [[2o2m]], [[2o2n]], [[1ysi]], [[1ysn]] - hBcl-xL + sulfonamide derivative – NMR<br />
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**[[3qkd]] - hBcl-xL + sulfonamide derivative<br />
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**[[2yxj]] - hBcl-xL + antagonist<br />
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**[[2pon]] - hBcl-xL + Beclin-1<br />
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**[[2p1l]] - hBcl-xL (mutant) + Beclin-1<br />
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**[[1g5j]] - hBcl-xL residues 1-209 + BAD peptide (mutant)<br />
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**[[3ihc]], [[3iih]], [[1pq0]] – mBcl-xL residues 1-196 – mouse<br />
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**[[3ihd]], [[3ihe]], [[3ihf]], [[3iig]], [[3ilb]], [[3ilc]] - mBcl-xL residues 1-196 (mutant)<br />
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**[[2bzw]] - mBcl-xL residues 1-211 + BAD<br />
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**[[1pq1]] - mBcl-xL residues 1-196 + Bcl-2-like protein 11<br />
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**[[1af3]] - rBcl-xL soluble domain<br />
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**[[1bxl]] - Bcl-xL + Bak peptide – ''Escherichia coli'' – NMR<br />
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*Bcl-2
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**[[1gjh]], [[1g5m]] – hBcl-2<br />
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**[[4aq3]], [[4man]] – hBcl-2 + inhibitor<br />
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**[[4lvt]], [[4lxd]] – hBcl-2 (mutant) + inhibitor<br />
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**[[2xa0]] – hBcl-2 residues 1-207 + apoptosis regulator BAX BH3 domain<br />
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**[[2o21]], [[2o22]], [[2o2f]], [[1ysw]] - hBcl-2 + sulfonamide derivative - NMR<br />
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**[[2kua]] – mBcl-2-L-10<br />
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**[[3io8]] - hBcl-2-L-1 + hBcl-2-L-11 BH3 peptide (mutant)<br />
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**[[3i1h]] - hBcl-2-L-5 + hBcl-2-L-7<br />
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**[[2yv6]], [[2imt]], [[2jcn]], [[2ims]] – hBcl-2-L-7<br />
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**[[3qbr]] - hBcl-2-L-7 + sjA<br />
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**[[2xpx]] - hBcl-2-L-7 fragment + BHRF1<br />
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**[[2vm6]] – hBcl-2A1 residues 1-149 + hBcl-2-L-11 peptide<br />
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**[[2nl9]] – hBcl-2-L-11 + Mcl-1<br />
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*Bcl-w
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**[[1o0l]], [[1mk3]] – hBcl-w (mutant)<br />
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**[[1zy3]] - hBcl-w (mutant) + BH3 peptide<br />
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*Mcl-1
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**[[2nla]] – rMcl-1 fragment + NoxaB BH3<br />
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**[[1wsx]] – mMcl-1 residues 152-308<br />
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**[[2jm6]], [[2rod]] – mMcl-1 fragment + NoxaB fragment – NMR<br />
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**[[2roc]] - mMcl-1 fragment + Puma<br />
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**[[3kz0]] - hMcl-1 + peptide MB7<br />
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**[[3mk8]] - hMcl-1 fragment<br />
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**[[2mhs]] - hMcl-1 fragment (mutant)<br />
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**[[3pk1]] – hMcl-1 fragment + hBcl-2-L-4 BH3 domain<br />
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**[[3kj0]], [[3kj1]], [[3kj2]], [[3io9]] - hMcl-1 fragment + hBcl-2-L-11 BH3 domain (mutant)<br />
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**[[3d7v]], [[2pqk]] - hMcl-1 fragment + hBcl-2-L-11 BIM BH3<br />
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**[[2kbw]] - hMcl-1 fragment + BID BH3 peptide – NMR<br />
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**[[3wix]], [[3wiy]], [[4oq5]], 4oq6]] - hMcl-1 fragment + inhibitor<br />
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**[[4bpj]] - hMcl-1 fragment + BH3 peptide <br />
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*M11
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**[[2o42]], [[2jbx]] – MvM11L – Myxoma virus<br />
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**[[2jby]] – MvM11L + Bcl-2 homologous antagonis <br />
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**[[3dvu]], [[3bl2]] – M11 + Beclin-1 – Murid herpesvirus<br />
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*N1L
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**[[2i39]] – VvN1L – Vaccinia virus<br />
 
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**[[4bbb]], [[4bbc]], [[4bbd]] – VvN1L (mutant)<br />
 
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}}
 
==References==
==References==

Current revision

NMR structure of bcl-2 1g5m

Drag the structure with the mouse to rotate

References

1. Mee Young Hong; Chapkin, Robert S.; Davidson, Laurie A.; Turner, Nancy D.; Morris, Jeffrey S.; Carroll, Raymond J.; Lupton, Joanne R.. Nutrition & Cancer, 2003, Vol. 46 Issue 1, p44-44, 8p; DOI: NO_DOI; (AN 10719727)

2. Reed JC, Zha H, Aime-Sempe C, Takayama S, Wang HG, Advances In Experimental Medicine And Biology, ISSN: 0065-2598, 1996; Vol. 406, pp. 99-112; PMID: 8910675

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