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4ydh

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==The structure of human FMNL1 N-terminal domains bound to Cdc42==
==The structure of human FMNL1 N-terminal domains bound to Cdc42==
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<StructureSection load='4ydh' size='340' side='right' caption='[[4ydh]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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<StructureSection load='4ydh' size='340' side='right'caption='[[4ydh]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ydh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YDH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YDH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ydh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YDH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yc7|4yc7]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ydh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ydh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ydh RCSB], [http://www.ebi.ac.uk/pdbsum/4ydh PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ydh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ydh OCA], [https://pdbe.org/4ydh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ydh RCSB], [https://www.ebi.ac.uk/pdbsum/4ydh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ydh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FMNL_HUMAN FMNL_HUMAN]] May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.<ref>PMID:21834987</ref> [[http://www.uniprot.org/uniprot/CDC42_HUMAN CDC42_HUMAN]] Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration.<ref>PMID:14978216</ref> <ref>PMID:15642749</ref> <ref>PMID:17038317</ref>
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[https://www.uniprot.org/uniprot/FMNL1_HUMAN FMNL1_HUMAN] May play a role in the control of cell motility and survival of macrophages (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape.<ref>PMID:21834987</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4ydh" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Anand, K]]
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[[Category: Homo sapiens]]
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[[Category: Geyer, M]]
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[[Category: Large Structures]]
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[[Category: Kuhn, S]]
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[[Category: Anand K]]
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[[Category: Actin cytoskeleton]]
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[[Category: Geyer M]]
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[[Category: Formin]]
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[[Category: Kuhn S]]
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[[Category: Gtpase]]
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[[Category: Signaling protein]]
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Current revision

The structure of human FMNL1 N-terminal domains bound to Cdc42

PDB ID 4ydh

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