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3ja8

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'''Unreleased structure'''
 
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The entry 3ja8 is ON HOLD
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==Cryo-EM structure of the MCM2-7 double hexamer==
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<SX load='3ja8' size='340' side='right' viewer='molstar' caption='[[3ja8]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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Authors: Li, N., Zhai, Y., Zhang, Y., Li, W., Yang, M., Lei, J., Tye, B.K., Gao, N.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ja8]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JA8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JA8 FirstGlance]. <br>
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Description: Cryo-EM study of the oligomer complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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[[Category: Yang, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ja8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ja8 OCA], [https://pdbe.org/3ja8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ja8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ja8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ja8 ProSAT]</span></td></tr>
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[[Category: Zhai, Y]]
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</table>
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[[Category: Tye, B.K]]
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== Function ==
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[[Category: Li, W]]
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[https://www.uniprot.org/uniprot/MCM2_YEAST MCM2_YEAST] Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity; specifically the MCM2-MCM5 association is proposed to be reversible and to mediate a open ring conformation which may facilitate DNA loading. Once loaded onto DNA, double hexamers can slide on dsDNA in the absence of ATPase activity. Necessary for cell growth.<ref>PMID:19896182</ref> <ref>PMID:19910535</ref>
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[[Category: Zhang, Y]]
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== References ==
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[[Category: Gao, N]]
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<references/>
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[[Category: Li, N]]
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__TOC__
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[[Category: Lei, J]]
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</SX>
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[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae S288C]]
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[[Category: Gao N]]
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[[Category: Lei J]]
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[[Category: Li N]]
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[[Category: Li W]]
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[[Category: Tye BK]]
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[[Category: Yang M]]
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[[Category: Zhai Y]]
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[[Category: Zhang Y]]

Current revision

Cryo-EM structure of the MCM2-7 double hexamer

3ja8, resolution 3.80Å

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