We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

383d

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:34, 3 April 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:383d.gif|left|200px]]
 
-
{{Structure
+
==Hydration and recognition of methylated CPG steps in DNA==
-
|PDB= 383d |SIZE=350|CAPTION= <scene name='initialview01'>383d</scene>, resolution 1.700&Aring;
+
<StructureSection load='383d' size='340' side='right'caption='[[383d]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
+
<table><tr><td colspan='2'>[[383d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=383D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=383D FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CM:5-METHYL-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>5CM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=383d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=383d OCA], [https://pdbe.org/383d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=383d RCSB], [https://www.ebi.ac.uk/pdbsum/383d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=383d ProSAT]</span></td></tr>
-
 
+
</table>
-
'''Hydration and recognition of methylated CPG steps in DNA'''
+
__TOC__
-
 
+
</StructureSection>
-
 
+
[[Category: Large Structures]]
-
==Overview==
+
[[Category: Mayer-Jung C]]
-
The analysis of the hydration pattern around methylated CpG steps in three high resolution (1.7, 2.15 and 2.2 A) crystal structures of A-DNA decamers reveals that the methyl groups of cytosine residues are well hydrated. In comparing the native structure with two structurally distinct forms of the decamer d(CCGCCGGCGG) fully methylated at its CpG steps, this study shows also that in certain structural and sequence contexts, the methylated cytosine base can be more hydrated that the unmodified one. These water molecules seem to be stabilized in front of the methyl group through the formation C-H...O interactions. In addition, these structures provide the first observation of magnesium cations bound to the major groove of A-DNA and reveal two distinct modes of metal binding in methylated and native duplexes. These findings suggest that methylated cytosine bases could be recognized by protein or DNA polar residues through their tightly bound water molecules.
+
[[Category: Moras D]]
-
 
+
[[Category: Timsit Y]]
-
==About this Structure==
+
-
383D is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=383D OCA].
+
-
 
+
-
==Reference==
+
-
Hydration and recognition of methylated CpG steps in DNA., Mayer-Jung C, Moras D, Timsit Y, EMBO J. 1998 May 1;17(9):2709-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9564052 9564052]
+
-
[[Category: Single protein]]
+
-
[[Category: Mayer-Jung, C.]]
+
-
[[Category: Moras, D.]]
+
-
[[Category: Timsit, Y.]]
+
-
[[Category: MG]]
+
-
[[Category: a-dna]]
+
-
[[Category: double helix]]
+
-
[[Category: modified deoxyribonucleic acid]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:55:10 2008''
+

Current revision

Hydration and recognition of methylated CPG steps in DNA

PDB ID 383d

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/383d"
Personal tools