4zw1

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m (Protected "4zw1" [edit=sysop:move=sysop])
Current revision (09:05, 20 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4zw1 is ON HOLD
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==Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer==
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<StructureSection load='4zw1' size='340' side='right'caption='[[4zw1]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4zw1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZW1 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4V1:2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-7-METHYL-5,6,7,8-TETRAHYDROPYRIDO[4,3 4,5]THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE'>4V1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zw1 OCA], [https://pdbe.org/4zw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zw1 RCSB], [https://www.ebi.ac.uk/pdbsum/4zw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zw1 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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Authors: Bo, L., Shouyue, Z., Mingrui, G., Mao, T.
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
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Description: Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Mingrui, G]]
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__TOC__
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[[Category: Shouyue, Z]]
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</StructureSection>
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[[Category: Bo, L]]
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[[Category: Homo sapiens]]
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[[Category: Mao, T]]
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[[Category: Large Structures]]
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[[Category: Guo M]]
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[[Category: Liu B]]
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[[Category: Tian M]]
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[[Category: Zhang S]]

Current revision

Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer

PDB ID 4zw1

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