3b5q

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[[Image:3b5q.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of a putative sulfatase (NP_810509.1) from Bacteroides thetaiotaomicron VPI-5482 at 2.40 A resolution==
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|PDB= 3b5q |SIZE=350|CAPTION= <scene name='initialview01'>3b5q</scene>, resolution 2.400&Aring;
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<StructureSection load='3b5q' size='340' side='right'caption='[[3b5q]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene> and <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>
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<table><tr><td colspan='2'>[[3b5q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron_VPI-5482 Bacteroides thetaiotaomicron VPI-5482]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B5Q FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE= NP_810509.1, BT_1596 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2 Bacteria])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b5q OCA], [https://pdbe.org/3b5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b5q RCSB], [https://www.ebi.ac.uk/pdbsum/3b5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b5q ProSAT], [https://www.topsan.org/Proteins/JCSG/3b5q TOPSAN]</span></td></tr>
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</table>
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'''Crystal structure of a putative sulfatase (NP_810509.1) from Bacteroides thetaiotaomicron VPI-5482 at 2.40 A resolution'''
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== Function ==
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[https://www.uniprot.org/uniprot/HEXSF_BACTN HEXSF_BACTN] Exosulfatase involved in the degradation of the glycosaminoglycans (GAGs) chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS). 2-O-sulfatase active on unsaturated non-reducing end hexuronate units. Has a slight preference for HS-derived structures (PubMed:25002587). GAG-specific sulfatases play a key role in the persistence of the major human gut symbiont B.thetaiotaomicron in the host gastrointestinal tract (PubMed:25002587).<ref>PMID:25002587</ref> <ref>PMID:25002587</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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3B5Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B5Q OCA].
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Check<jmol>
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[[Category: Bacteria]]
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<jmolCheckbox>
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[[Category: Single protein]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b5/3b5q_consurf.spt"</scriptWhenChecked>
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[[Category: JCSG, Joint Center for Structural Genomics.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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[[Category: CL]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: EDO]]
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</jmolCheckbox>
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[[Category: EPE]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b5q ConSurf].
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[[Category: PEG]]
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<div style="clear:both"></div>
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[[Category: ZN]]
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== References ==
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[[Category: hydrolase]]
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<references/>
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[[Category: jcsg]]
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__TOC__
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[[Category: joint center for structural genomic]]
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</StructureSection>
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[[Category: np_810509 1]]
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[[Category: Bacteroides thetaiotaomicron VPI-5482]]
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[[Category: protein structure initiative]]
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[[Category: Large Structures]]
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[[Category: psi-2]]
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[[Category: putative sulfatase]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:56:20 2008''
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Current revision

Crystal structure of a putative sulfatase (NP_810509.1) from Bacteroides thetaiotaomicron VPI-5482 at 2.40 A resolution

PDB ID 3b5q

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