4yoz
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==p107 pocket domain in complex with HPV E7 peptide== | |
| - | + | <StructureSection load='4yoz' size='340' side='right'caption='[[4yoz]], [[Resolution|resolution]] 2.25Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4yoz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_papillomavirus Human papillomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YOZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YOZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.245Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yoz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yoz OCA], [https://pdbe.org/4yoz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yoz RCSB], [https://www.ebi.ac.uk/pdbsum/4yoz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yoz ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Guiley | + | == Function == |
| - | [[Category: Litovchick | + | [https://www.uniprot.org/uniprot/RBL1_HUMAN RBL1_HUMAN] Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation. Forms a complex with adenovirus E1A and with SV40 large T antigen. May bind and modulate functionally certain cellular proteins with which T and E1A compete for pocket binding. May act as a tumor suppressor. |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Human papillomavirus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Felthousen JG]] | ||
| + | [[Category: Guiley KZ]] | ||
| + | [[Category: Liban TJ]] | ||
| + | [[Category: Litovchick L]] | ||
| + | [[Category: Ramanan P]] | ||
| + | [[Category: Rubin SM]] | ||
Current revision
p107 pocket domain in complex with HPV E7 peptide
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