3b8e

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[[Image:3b8e.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of the sodium-potassium pump==
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|PDB= 3b8e |SIZE=350|CAPTION= <scene name='initialview01'>3b8e</scene>, resolution 3.5&Aring;
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<StructureSection load='3b8e' size='340' side='right'caption='[[3b8e]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=RB:RUBIDIUM+ION'>RB</scene>, <scene name='pdbligand=MF4:TETRAFLUOROMAGNESATE(2-)'>MF4</scene> and <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>
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<table><tr><td colspan='2'>[[3b8e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. The October 2009 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Sodium-Potassium Pump'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2009_10 10.2210/rcsb_pdb/mom_2009_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B8E FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Sodium/potassium-exchanging_ATPase Sodium/potassium-exchanging ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.9 3.6.3.9]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MF4:TETRAFLUOROMAGNESATE(2-)'>MF4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=RB:RUBIDIUM+ION'>RB</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b8e OCA], [https://pdbe.org/3b8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b8e RCSB], [https://www.ebi.ac.uk/pdbsum/3b8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b8e ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AT1A1_PIG AT1A1_PIG] This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/3b8e_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b8e ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of the sodium-potassium pump'''
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==See Also==
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*[[ATPase 3D structures|ATPase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3B8E is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B8E OCA].
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[[Category: Large Structures]]
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[[Category: Protein complex]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Sodium/potassium-exchanging ATPase]]
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[[Category: Sodium-Potassium Pump]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Andersen, J P.]]
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[[Category: Andersen JP]]
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[[Category: Morth, J P.]]
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[[Category: Morth JP]]
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[[Category: Nissen, P.]]
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[[Category: Nissen P]]
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[[Category: Pedersen, P B.]]
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[[Category: Pedersen PB]]
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[[Category: Petersen, J.]]
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[[Category: Petersen J]]
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[[Category: Soerensen, T L.M.]]
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[[Category: Soerensen TLM]]
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[[Category: Toustrup-Jensen, M S.]]
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[[Category: Toustrup-Jensen MS]]
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[[Category: Vilsen, B.]]
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[[Category: Vilsen B]]
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[[Category: MF4]]
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[[Category: MG]]
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[[Category: PC1]]
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[[Category: RB]]
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[[Category: atp-binding]]
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[[Category: calcium transport]]
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[[Category: cation pump]]
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[[Category: glycoprotein]]
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[[Category: hydrolase]]
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[[Category: hydrolase/transport protein complex]]
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[[Category: ion transport]]
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[[Category: k+-atpase]]
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[[Category: magnesium]]
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[[Category: membrane potential]]
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[[Category: membrane protein]]
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[[Category: metal-binding]]
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[[Category: na+]]
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[[Category: nucleotide-binding]]
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[[Category: p-type atpase]]
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[[Category: phosphorylation]]
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[[Category: potassium]]
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[[Category: potassium transport]]
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[[Category: signal-anchor]]
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[[Category: sodium]]
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[[Category: sodium transport]]
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[[Category: sodium/potassium transport]]
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[[Category: transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:57:02 2008''
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Current revision

Crystal structure of the sodium-potassium pump

PDB ID 3b8e

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