3b93

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[[Image:3b93.jpg|left|200px]]
 
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{{Structure
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==crystal structure of human GITRL==
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|PDB= 3b93 |SIZE=350|CAPTION= <scene name='initialview01'>3b93</scene>, resolution 2.2&Aring;
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<StructureSection load='3b93' size='340' side='right'caption='[[3b93]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[3b93]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B93 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B93 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3b94|3b94]]</div></td></tr>
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|GENE= TNFSF18, AITRL, GITRL, TL6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFSF18, AITRL, GITRL, TL6 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b93 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b93 OCA], [https://pdbe.org/3b93 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b93 RCSB], [https://www.ebi.ac.uk/pdbsum/3b93 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b93 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/TNF18_HUMAN TNF18_HUMAN]] Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B.<ref>PMID:17449724</ref> <ref>PMID:18040044</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b9/3b93_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b93 ConSurf].
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<div style="clear:both"></div>
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'''crystal structure of human GITRL'''
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==See Also==
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*[[Tumor necrosis factor ligand superfamily 3D structures|Tumor necrosis factor ligand superfamily 3D structures]]
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*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
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==About this Structure==
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== References ==
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3B93 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B93 OCA].
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<references/>
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[[Category: Homo sapiens]]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Song, X M.]]
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[[Category: Human]]
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[[Category: Zhou, Z C.]]
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[[Category: Large Structures]]
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[[Category: asymmetric]]
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[[Category: Song, X M]]
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[[Category: c2 spacegroup]]
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[[Category: Zhou, Z C]]
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[[Category: cytokine]]
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[[Category: Asymmetric]]
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[[Category: glycoprotein]]
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[[Category: C2 spacegroup]]
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[[Category: membrane]]
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[[Category: Cytokine]]
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[[Category: open trimer]]
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[[Category: Glycoprotein]]
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[[Category: signal-anchor]]
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[[Category: Membrane]]
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[[Category: transmembrane]]
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[[Category: Open trimer]]
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[[Category: Signal-anchor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:57:13 2008''
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[[Category: Transmembrane]]

Current revision

crystal structure of human GITRL

PDB ID 3b93

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OCA

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