4zwv

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==Crystal Structure of Aminotransferase AtmS13 from Actinomadura melliaura==
==Crystal Structure of Aminotransferase AtmS13 from Actinomadura melliaura==
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<StructureSection load='4zwv' size='340' side='right' caption='[[4zwv]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='4zwv' size='340' side='right'caption='[[4zwv]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zwv]] is a 2 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4rxk 4rxk]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZWV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zwv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinomadura_melliaura Actinomadura melliaura]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZWV FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.503&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:2-LYSINE(3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHANE)'>LLP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zwv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zwv RCSB], [http://www.ebi.ac.uk/pdbsum/4zwv PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zwv OCA], [https://pdbe.org/4zwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zwv RCSB], [https://www.ebi.ac.uk/pdbsum/4zwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zwv ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q0H2X1_9ACTN Q0H2X1_9ACTN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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AT2433 from Actinomadura melliaura is an indolocarbazole antitumor antibiotic structurally distinguished by its unique aminodideoxypentose-containing disaccharide moiety. The corresponding sugar nucleotide-based biosynthetic pathway for this unusual sugar derives from comparative genomics where AtmS13 has been suggested as the contributing sugar aminotransferase (SAT). Determination of the AtmS13 X-ray structure at 1.50 A resolution reveals it as a member of the aspartate aminotransferase fold type I (AAT-I). Structural comparisons of AtmS13 with homologous SATs that act upon similar substrates implicate potential active site residues that contribute to distinctions in sugar C5 (hexose versus pentose) and/or sugar C2 (deoxy versus hydroxyl) substrate specificity. This article is protected by copyright. All rights reserved.
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Structural characterization of AtmS13, a putative sugar aminotransferase involved in indolocarbazole AT2433 aminopentose biosynthesis.,Singh S, Kim Y, Wang F, Bigelow L, Endres M, Kharel MK, Babnigg G, Bingman CA, Joachimiak A, Thorson JS, Phillips GN Proteins. 2015 Jun 9. doi: 10.1002/prot.24844. PMID:26061967<ref>PMID:26061967</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 4zwv" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bigelow, L]]
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[[Category: Actinomadura melliaura]]
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[[Category: Endres, M]]
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[[Category: Large Structures]]
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[[Category: Joachimiak, A]]
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[[Category: Bigelow L]]
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[[Category: Kim, Y]]
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[[Category: Endres M]]
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[[Category: Structural genomic]]
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[[Category: Joachimiak A]]
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[[Category: NatPro, Enzyme Discovery for Natural Product Biosynthesis]]
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[[Category: Kim Y]]
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[[Category: Phillips, G N]]
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[[Category: Phillips Jr GN]]
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[[Category: Wang, F]]
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[[Category: Wang F]]
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[[Category: Aminotransferase]]
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[[Category: Enzyme discovery for natural product biosynthesis]]
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[[Category: Mcsg]]
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[[Category: Natpro]]
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[[Category: PSI, Protein structure initiative]]
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Current revision

Crystal Structure of Aminotransferase AtmS13 from Actinomadura melliaura

PDB ID 4zwv

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