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4x3i

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==The crystal structure of Arc N-lobe complexed with CAMK2A fragment==
==The crystal structure of Arc N-lobe complexed with CAMK2A fragment==
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<StructureSection load='4x3i' size='340' side='right' caption='[[4x3i]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='4x3i' size='340' side='right'caption='[[4x3i]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4x3i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X3I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X3I FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4x3i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4X3I FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4x3h|4x3h]], [[4x3x|4x3x]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium/calmodulin-dependent_protein_kinase Calcium/calmodulin-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.17 2.7.11.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4x3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x3i OCA], [https://pdbe.org/4x3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4x3i RCSB], [https://www.ebi.ac.uk/pdbsum/4x3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4x3i ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x3i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x3i RCSB], [http://www.ebi.ac.uk/pdbsum/4x3i PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ARC_RAT ARC_RAT]] Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity). Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.<ref>PMID:17088212</ref> <ref>PMID:17088213</ref>
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[https://www.uniprot.org/uniprot/ARC_RAT ARC_RAT] Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration (By similarity). Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.<ref>PMID:17088212</ref> <ref>PMID:17088213</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4x3i" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Calcium/calmodulin-dependent protein kinase]]
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[[Category: Large Structures]]
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[[Category: Leahy, D]]
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[[Category: Mus musculus]]
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[[Category: Ward, M]]
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[[Category: Rattus norvegicus]]
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[[Category: Worley, P]]
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[[Category: Leahy D]]
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[[Category: Zhang, W]]
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[[Category: Ward M]]
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[[Category: Endocytosis mediator]]
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[[Category: Worley P]]
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[[Category: Zhang W]]

Current revision

The crystal structure of Arc N-lobe complexed with CAMK2A fragment

PDB ID 4x3i

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