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4yk8

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==Crystal structure of the Atg101-Atg13 complex from fission yeast==
==Crystal structure of the Atg101-Atg13 complex from fission yeast==
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<StructureSection load='4yk8' size='340' side='right' caption='[[4yk8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='4yk8' size='340' side='right'caption='[[4yk8]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yk8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YK8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YK8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yk8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YK8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YK8 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yk8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yk8 RCSB], [http://www.ebi.ac.uk/pdbsum/4yk8 PDBsum]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yk8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yk8 OCA], [https://pdbe.org/4yk8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yk8 RCSB], [https://www.ebi.ac.uk/pdbsum/4yk8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yk8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MUG66_SCHPO MUG66_SCHPO]] Autophagy factor required for autophagosome formation (By similarity). Has a role in meiosis and sporulation.<ref>PMID:16303567</ref> [[http://www.uniprot.org/uniprot/ATG13_SCHPO ATG13_SCHPO]] Activates the atg1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Autophagy functions to supply nitrogen and is activated when cells cannot access exogenous nitrogen, thus ensuring that they can adapt and subsequently propagate. Finally, atg13 is also required for glycogen storage during stationary phase and has a role in meiosis and sporulation.<ref>PMID:16303567</ref> <ref>PMID:17295836</ref> <ref>PMID:19778961</ref>
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[https://www.uniprot.org/uniprot/MUG66_SCHPO MUG66_SCHPO] Autophagy factor required for autophagosome formation (By similarity). Has a role in meiosis and sporulation.<ref>PMID:16303567</ref>
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==See Also==
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*[[Autophagy-related protein 3D structures|Autophagy-related protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Noda, N N]]
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[[Category: Large Structures]]
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[[Category: Suzuki, H]]
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[[Category: Schizosaccharomyces pombe 972h-]]
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[[Category: Autophagy]]
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[[Category: Noda NN]]
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[[Category: Horma]]
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[[Category: Suzuki H]]
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[[Category: Protein transport]]
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Current revision

Crystal structure of the Atg101-Atg13 complex from fission yeast

PDB ID 4yk8

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