SandboxWI01

(Difference between revisions)

Current revision

↑ Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649

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 ==Your Heading Here (maybe something like 'Structure')==
 <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
-This is a default text for your page '''SandboxWI01'''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
-You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
+ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.
+Tacrine is a reversible inhibitor of cholinesterase. It was the first FDA approved drug for the treatment of Alzheimer's disease.
+Tacrine’s ring is stacked between the aromatic rings of tryptophan 84 and phenylalanine 330 (W84 and F330).
+<scene name='70/703966/Sandwich/1'>Inhibitor sandwich</scene>
+This example is at [[Proteopedia:DIY:Scenes]]
+<ref>PMID:8415649</ref> to the rescue.
 == Function ==