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4nc9

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==Crystal structure of phosphatidyl mannosyltransferase PimA==
==Crystal structure of phosphatidyl mannosyltransferase PimA==
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<StructureSection load='4nc9' size='340' side='right' caption='[[4nc9]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
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<StructureSection load='4nc9' size='340' side='right'caption='[[4nc9]], [[Resolution|resolution]] 3.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4nc9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NC9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NC9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4nc9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4NC9 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4n9w|4n9w]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.192&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.57 2.4.1.57] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4nc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nc9 OCA], [https://pdbe.org/4nc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4nc9 RCSB], [https://www.ebi.ac.uk/pdbsum/4nc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4nc9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nc9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nc9 RCSB], [http://www.ebi.ac.uk/pdbsum/4nc9 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PIMA_MYCS2 PIMA_MYCS2]] Catalyzes the addition of a mannose residue from GDP-D-mannose to the position 2 of a phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Contrary to PimB, the mannosyltransferase PimA is unable to transfer a mannose residue to the position 6 of the phosphatidyl-myo-inositola of PIM1.<ref>PMID:12068013</ref> <ref>PMID:19638342</ref>
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[https://www.uniprot.org/uniprot/PIMA_MYCS2 PIMA_MYCS2] Catalyzes the addition of a mannose residue from GDP-D-mannose to the position 2 of a phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Contrary to PimB, the mannosyltransferase PimA is unable to transfer a mannose residue to the position 6 of the phosphatidyl-myo-inositola of PIM1.<ref>PMID:12068013</ref> <ref>PMID:19638342</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4nc9" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Transferase]]
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[[Category: Large Structures]]
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[[Category: Albesa-Jove, D]]
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[[Category: Mycolicibacterium smegmatis MC2 155]]
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[[Category: Alzari, P M]]
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[[Category: Albesa-Jove D]]
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[[Category: Bellinzoni, M]]
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[[Category: Alzari PM]]
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[[Category: Giganti, D]]
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[[Category: Bellinzoni M]]
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[[Category: Guerin, M E]]
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[[Category: Giganti D]]
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[[Category: Gt-b]]
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[[Category: Guerin ME]]

Current revision

Crystal structure of phosphatidyl mannosyltransferase PimA

PDB ID 4nc9

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