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3bgv

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[[Image:3bgv.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with SAH==
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|PDB= 3bgv |SIZE=350|CAPTION= <scene name='initialview01'>3bgv</scene>, resolution 2.30&Aring;
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<StructureSection load='3bgv' size='340' side='right'caption='[[3bgv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
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<table><tr><td colspan='2'>[[3bgv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BGV FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/mRNA_(guanine-N(7)-)-methyltransferase mRNA (guanine-N(7)-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.56 2.1.1.56]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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|GENE= RNMT, KIAA0398 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bgv OCA], [https://pdbe.org/3bgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bgv RCSB], [https://www.ebi.ac.uk/pdbsum/3bgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bgv ProSAT]</span></td></tr>
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</table>
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'''The crystals structure of mRNA cap guanine-N7 methyltransferase'''
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== Function ==
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[https://www.uniprot.org/uniprot/MCES_HUMAN MCES_HUMAN] mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC.<ref>PMID:9790902</ref> <ref>PMID:9705270</ref> <ref>PMID:10347220</ref> <ref>PMID:22099306</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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3BGV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BGV OCA].
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bg/3bgv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bgv ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: mRNA (guanine-N(7)-)-methyltransferase]]
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[[Category: Antoshenko T]]
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[[Category: Antoshenko, T.]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Bochkarev A]]
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[[Category: Bochkarev, A.]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M.]]
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[[Category: Lunin VV]]
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[[Category: Lunin, V V.]]
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[[Category: MacKenzie F]]
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[[Category: MacKenzie, F.]]
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[[Category: Min J]]
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[[Category: Min, J.]]
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[[Category: Plotnikov AN]]
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[[Category: Plotnikov, A N.]]
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[[Category: Weigelt J]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Wu H]]
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[[Category: Weigelt, J.]]
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[[Category: Zeng H]]
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[[Category: Wu, H.]]
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[[Category: Zeng, H.]]
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[[Category: SAH]]
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[[Category: alternative splicing]]
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[[Category: methyltransferase]]
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[[Category: mrna capping]]
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[[Category: mrna processing]]
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[[Category: nucleus]]
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[[Category: phosphoprotein]]
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[[Category: rna-binding]]
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[[Category: s-adenosyl-l-methionine]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:58:47 2008''
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Current revision

Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with SAH

PDB ID 3bgv

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