5bs3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of S.A. gyrase in complex with Compound 7== | |
| + | <StructureSection load='5bs3' size='340' side='right'caption='[[5bs3]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5bs3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus] and [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_ED98 Staphylococcus aureus subsp. aureus ED98]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BS3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BS3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=WCP:(4R)-3-FLUORO-4-HYDROXY-4-{[(1R,4R)-4-{[(3-OXO-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZIN-6-YL)METHYL]AMINO}-2-OXABICYCLO[2.2.2]OCT-1-YL]METHYL}-4,5-DIHYDRO-7H-PYRROLO[3,2,1-DE][1,5]NAPHTHYRIDIN-7-ONE'>WCP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bs3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bs3 OCA], [https://pdbe.org/5bs3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bs3 RCSB], [https://www.ebi.ac.uk/pdbsum/5bs3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bs3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GYRB_STAAU GYRB_STAAU] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898][https://www.uniprot.org/uniprot/GYRA_STAAU GYRA_STAAU] A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.[HAMAP-Rule:MF_01897] | ||
| - | + | ==See Also== | |
| - | + | *[[Gyrase 3D Structures|Gyrase 3D Structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Lu | + | [[Category: Staphylococcus aureus]] |
| - | [[Category: Patel | + | [[Category: Staphylococcus aureus subsp. aureus ED98]] |
| + | [[Category: Lu J]] | ||
| + | [[Category: Patel S]] | ||
| + | [[Category: Soisson S]] | ||
Current revision
Crystal Structure of S.A. gyrase in complex with Compound 7
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