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3bkd

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[[Image:3bkd.jpg|left|200px]]
 
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{{Structure
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==High resolution Crystal structure of Transmembrane domain of M2 protein==
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|PDB= 3bkd |SIZE=350|CAPTION= <scene name='initialview01'>3bkd</scene>, resolution 2.05&Aring;
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<StructureSection load='3bkd' size='340' side='right'caption='[[3bkd]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Bog+Binding+Site+For+Residue+B+301'>AC1</scene>, <scene name='pdbsite=AC2:Bog+Binding+Site+For+Residue+A+302'>AC2</scene>, <scene name='pdbsite=AC3:Bog+Binding+Site+For+Residue+C+303'>AC3</scene>, <scene name='pdbsite=AC4:Bog+Binding+Site+For+Residue+G+701'>AC4</scene>, <scene name='pdbsite=AC5:Bog+Binding+Site+For+Residue+E+702'>AC5</scene>, <scene name='pdbsite=AC6:Bog+Binding+Site+For+Residue+G+703'>AC6</scene>, <scene name='pdbsite=AC7:Cl+Binding+Site+For+Residue+A+101'>AC7</scene>, <scene name='pdbsite=AC8:Cl+Binding+Site+For+Residue+E+501'>AC8</scene>, <scene name='pdbsite=AC9:Nh2+Binding+Site+For+Residue+A+47'>AC9</scene>, <scene name='pdbsite=BC1:Nh2+Binding+Site+For+Residue+B+47'>BC1</scene>, <scene name='pdbsite=BC2:Nh2+Binding+Site+For+Residue+C+47'>BC2</scene>, <scene name='pdbsite=BC3:Nh2+Binding+Site+For+Residue+D+47'>BC3</scene>, <scene name='pdbsite=BC4:Nh2+Binding+Site+For+Residue+E+47'>BC4</scene>, <scene name='pdbsite=BC5:Nh2+Binding+Site+For+Residue+F+47'>BC5</scene>, <scene name='pdbsite=BC6:Nh2+Binding+Site+For+Residue+G+47'>BC6</scene>, <scene name='pdbsite=BC7:Nh2+Binding+Site+For+Residue+H+47'>BC7</scene>, <scene name='pdbsite=BC8:Peg+Binding+Site+For+Residue+E+802'>BC8</scene> and <scene name='pdbsite=BC9:Peg+Binding+Site+For+Residue+A+803'>BC9</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene> and <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>
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<table><tr><td colspan='2'>[[3bkd]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Chicken/Hong_Kong/G23/97(H9N2)) Influenza A virus (A/Chicken/Hong Kong/G23/97(H9N2))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BKD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BKD FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bkd OCA], [https://pdbe.org/3bkd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bkd RCSB], [https://www.ebi.ac.uk/pdbsum/3bkd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bkd ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9Q0P0_9INFA Q9Q0P0_9INFA] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry.[RuleBase:RU361247] Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation.[SAAS:SAAS00108379]
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'''High resolution Crystal structure of Transmembrane domain of M2 protein'''
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
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*[[M2 protein|M2 protein]]
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==About this Structure==
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__TOC__
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3BKD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BKD OCA].
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Acharya, R.]]
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[[Category: Acharya R]]
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[[Category: Salom, D.]]
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[[Category: Salom D]]
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[[Category: Stouffer, A L.]]
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[[Category: Stouffer AL]]
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[[Category: BOG]]
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[[Category: CL]]
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[[Category: NH2]]
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[[Category: PEG]]
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[[Category: influenza a virus m2 protein]]
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[[Category: m2tm]]
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[[Category: membrane protein]]
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[[Category: proton channel]]
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[[Category: viral protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:59:42 2008''
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Current revision

High resolution Crystal structure of Transmembrane domain of M2 protein

PDB ID 3bkd

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OCA

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