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5byl
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5byl is ON HOLD Authors: Caldwell, S.J., Berghuis, A.M. Description: Aminoglycoside Phosphotransferase (2'')-Ia (CTD of APH(6')-Ie/APH(2'')-Ia) in ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Aminoglycoside Phosphotransferase (2'')-Ia (CTD of AAC(6')-Ie/APH(2'')-Ia) in complex with GMPPCP and Magnesium== | |
| - | + | <StructureSection load='5byl' size='340' side='right'caption='[[5byl]], [[Resolution|resolution]] 2.15Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5byl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BYL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5byl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5byl OCA], [https://pdbe.org/5byl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5byl RCSB], [https://www.ebi.ac.uk/pdbsum/5byl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5byl ProSAT]</span></td></tr> |
| - | [[Category: Berghuis | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AACA_STAAU AACA_STAAU] Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Staphylococcus aureus]] | ||
| + | [[Category: Berghuis AM]] | ||
| + | [[Category: Caldwell SJ]] | ||
Current revision
Aminoglycoside Phosphotransferase (2)-Ia (CTD of AAC(6')-Ie/APH(2)-Ia) in complex with GMPPCP and Magnesium
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