4qkz

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==X-ray structure of the catalytic domain of MMP-8 with the inhibitor ML115==
==X-ray structure of the catalytic domain of MMP-8 with the inhibitor ML115==
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<StructureSection load='4qkz' size='340' side='right' caption='[[4qkz]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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<StructureSection load='4qkz' size='340' side='right'caption='[[4qkz]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4qkz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QKZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QKZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4qkz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QKZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QKZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=QZK:{[(BIPHENYL-4-YLSULFONYL)AMINO]METHANEDIYL}BIS(PHOSPHONIC+ACID)'>QZK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Neutrophil_collagenase Neutrophil collagenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.34 3.4.24.34] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=QZK:{[(BIPHENYL-4-YLSULFONYL)AMINO]METHANEDIYL}BIS(PHOSPHONIC+ACID)'>QZK</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qkz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qkz RCSB], [http://www.ebi.ac.uk/pdbsum/4qkz PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qkz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qkz OCA], [https://pdbe.org/4qkz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qkz RCSB], [https://www.ebi.ac.uk/pdbsum/4qkz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qkz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MMP8_HUMAN MMP8_HUMAN]] Can degrade fibrillar type I, II, and III collagens.
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[https://www.uniprot.org/uniprot/MMP8_HUMAN MMP8_HUMAN] Can degrade fibrillar type I, II, and III collagens.
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==See Also==
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Neutrophil collagenase]]
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[[Category: Homo sapiens]]
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[[Category: Capelli, D]]
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[[Category: Large Structures]]
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[[Category: Montanari, R]]
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[[Category: Capelli D]]
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[[Category: Pochetti, G]]
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[[Category: Montanari R]]
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[[Category: Tortorella, P]]
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[[Category: Pochetti G]]
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[[Category: Hydrolase]]
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[[Category: Tortorella P]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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Current revision

X-ray structure of the catalytic domain of MMP-8 with the inhibitor ML115

PDB ID 4qkz

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