This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5bnv

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:17, 6 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
 +
==Crystal structure of Human MCM2 HBD chaperoning a histone H3-H4 tetramer==
==Crystal structure of Human MCM2 HBD chaperoning a histone H3-H4 tetramer==
-
<StructureSection load='5bnv' size='340' side='right' caption='[[5bnv]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
+
<StructureSection load='5bnv' size='340' side='right'caption='[[5bnv]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5bnv]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BNV FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5bnv]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BNV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BNV FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.795&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5bnx|5bnx]], [[5bo0|5bo0]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bnv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bnv RCSB], [http://www.ebi.ac.uk/pdbsum/5bnv PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bnv OCA], [https://pdbe.org/5bnv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bnv RCSB], [https://www.ebi.ac.uk/pdbsum/5bnv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bnv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/MCM2_HUMAN MCM2_HUMAN]] Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.<ref>PMID:8175912</ref>
+
[https://www.uniprot.org/uniprot/H33_HUMAN H33_HUMAN]
-
== References ==
+
 
-
<references/>
+
==See Also==
 +
*[[Histone 3D structures|Histone 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Huang, H]]
+
[[Category: Homo sapiens]]
-
[[Category: Patel, D J]]
+
[[Category: Large Structures]]
-
[[Category: Chaperone-dna binding protein complex]]
+
[[Category: Huang H]]
-
[[Category: Dna replication]]
+
[[Category: Patel DJ]]
-
[[Category: H3-h4 tetramer]]
+
-
[[Category: Histone chaperone]]
+
-
[[Category: Mcm2 helicase]]
+

Current revision

Crystal structure of Human MCM2 HBD chaperoning a histone H3-H4 tetramer

PDB ID 5bnv

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5bnv"
Personal tools