5c28
From Proteopedia
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(New page: '''Unreleased structure''' The entry 5c28 is ON HOLD Authors: Yan, Y. Description: Category: Unreleased Structures Category: Yan, Y) |
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| - | '''Unreleased structure''' | ||
| - | + | ==PDE10 complexed with 6-chloro-2-cyclopropyl-5-methyl-pyrimidin-4-amine== | |
| + | <StructureSection load='5c28' size='340' side='right'caption='[[5c28]], [[Resolution|resolution]] 1.56Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5c28]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C28 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4XV:6-CHLORO-2-CYCLOPROPYL-5-METHYLPYRIMIDIN-4-AMINE'>4XV</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c28 OCA], [https://pdbe.org/5c28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c28 RCSB], [https://www.ebi.ac.uk/pdbsum/5c28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c28 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Yan | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Yan Y]] | ||
Current revision
PDE10 complexed with 6-chloro-2-cyclopropyl-5-methyl-pyrimidin-4-amine
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