5c3l
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the metazoan Nup62.Nup58.Nup54 nucleoporin complex.== | |
| + | <StructureSection load='5c3l' size='340' side='right'caption='[[5c3l]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5c3l]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelus_dromedarius Camelus dromedarius] and [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C3L FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c3l OCA], [https://pdbe.org/5c3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c3l RCSB], [https://www.ebi.ac.uk/pdbsum/5c3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c3l ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/K9ZTJ6_XENLA K9ZTJ6_XENLA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Nuclear pore complexes (NPCs) conduct nucleocytoplasmic transport and gain transport selectivity through nucleoporin FG domains. Here, we report a structural analysis of the FG Nup62*58*54 complex, which is a crucial component of the transport system. It comprises a approximately 13 nm long trimerization interface with an unusual 2W3F coil, a canonical heterotrimeric coiled coil, and a kink that enforces a compact six-helix bundle. Nup54 also contains a ferredoxin-like domain. We further identified a heterotrimeric Nup93-binding module for NPC anchorage. The quaternary structure alternations in the Nup62 complex, which were previously proposed to trigger a general NPC-gating, are incompatible with the trimer structure. We suggest that the highly elongated Nup62 complex projects barrier-forming FG-repeats far into the central NPC channel, supporting a barrier that guards the entire cross-section. | ||
| - | + | Crystal structure of the metazoan Nup62*Nup58*Nup54 nucleoporin complex.,Chug H, Trakhanov S, Hulsmann BB, Pleiner T, Gorlich D Science. 2015 Aug 20. pii: aac7420. PMID:26292704<ref>PMID:26292704</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5c3l" style="background-color:#fffaf0;"></div> |
| - | [[Category: Chug | + | |
| - | [[Category: | + | ==See Also== |
| - | [[Category: | + | *[[Nucleoporin 3D structures|Nucleoporin 3D structures]] |
| - | [[Category: Pleiner | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Camelus dromedarius]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Xenopus laevis]] | ||
| + | [[Category: Chug H]] | ||
| + | [[Category: Gorlich D]] | ||
| + | [[Category: Hulsmann BB]] | ||
| + | [[Category: Pleiner T]] | ||
| + | [[Category: Trakhanov S]] | ||
Current revision
Structure of the metazoan Nup62.Nup58.Nup54 nucleoporin complex.
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