5c4s
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5c4s is ON HOLD Authors: Gopal Parthasarathy, Stephen Soisson Description: Identification of a Novel Allosteric Binding Site for RORgt Inhibitors [...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Identification of a Novel Allosteric Binding Site for RORgt Inhibitors== | |
| - | + | <StructureSection load='5c4s' size='340' side='right'caption='[[5c4s]], [[Resolution|resolution]] 2.23Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5c4s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C4S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C4S FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4Y5:4-{1-[2-CHLORO-6-(TRIFLUOROMETHYL)BENZOYL]-4-FLUORO-1H-INDAZOL-3-YL}-3-FLUOROBENZOIC+ACID'>4Y5</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c4s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c4s OCA], [https://pdbe.org/5c4s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c4s RCSB], [https://www.ebi.ac.uk/pdbsum/5c4s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c4s ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Parthasarathy G]] | ||
| + | [[Category: Soisson S]] | ||
Current revision
Identification of a Novel Allosteric Binding Site for RORgt Inhibitors
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