4qpf

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (17:34, 20 September 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
 +
==New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption==
==New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption==
-
<StructureSection load='4qpf' size='340' side='right' caption='[[4qpf]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
+
<StructureSection load='4qpf' size='340' side='right'caption='[[4qpf]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4qpf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QPF FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4qpf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4QPF FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=39L:[1-FLUORO-2-(IMIDAZO[1,2-A]PYRIDIN-3-YL)ETHANE-1,1-DIYL]BIS(PHOSPHONIC+ACID)'>39L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zw5|1zw5]], [[1yq7|1yq7]], [[2vf6|2vf6]], [[3b7l|3b7l]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=39L:[1-FLUORO-2-(IMIDAZO[1,2-A]PYRIDIN-3-YL)ETHANE-1,1-DIYL]BIS(PHOSPHONIC+ACID)'>39L</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qpf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qpf RCSB], [http://www.ebi.ac.uk/pdbsum/4qpf PDBsum]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4qpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qpf OCA], [https://pdbe.org/4qpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4qpf RCSB], [https://www.ebi.ac.uk/pdbsum/4qpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4qpf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
+
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
 +
 
 +
==See Also==
 +
*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Barnett, B L]]
+
[[Category: Homo sapiens]]
-
[[Category: Duan, Z]]
+
[[Category: Large Structures]]
-
[[Category: Dunford, J E]]
+
[[Category: Barnett BL]]
-
[[Category: Ebetino, F H]]
+
[[Category: Duan Z]]
-
[[Category: Jeans, G]]
+
[[Category: Dunford JE]]
-
[[Category: Kwaasi, A A]]
+
[[Category: Ebetino FH]]
-
[[Category: Lundy, M]]
+
[[Category: Jeans G]]
-
[[Category: Mazur, A]]
+
[[Category: Kwaasi AA]]
-
[[Category: Russell, R G.G]]
+
[[Category: Lundy M]]
-
[[Category: Triffitt, J]]
+
[[Category: Mazur A]]
-
[[Category: All-alpha helical prenyltransferase]]
+
[[Category: Russell RGG]]
-
[[Category: Bisphosphonate]]
+
[[Category: Triffitt J]]
-
[[Category: Cholesterol synthesis]]
+
-
[[Category: Dimethylallyl pyrophosphate]]
+
-
[[Category: Isopentyl pyrophosphate]]
+
-
[[Category: Isoprene biosynthesis]]
+
-
[[Category: Isoprenoid pathway]]
+
-
[[Category: Lipid synthesis]]
+
-
[[Category: Steroid biosynthesis]]
+
-
[[Category: Transferase]]
+

Current revision

New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption

PDB ID 4qpf

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4qpf"
Personal tools