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2n4j
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 2n4j is ON HOLD Authors: Maiti, M., Lescrinier, E., Herdewijn, P. Description: Solution structure of a self complementary Xylonucleic Acid duplex [...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of a self complementary Xylonucleic Acid duplex== | |
| + | <StructureSection load='2n4j' size='340' side='right'caption='[[2n4j]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2n4j]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N4J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N4J FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8XA:9-(5-O-PHOSPHONO-BETA-D-XYLOFURANOSYL)-9H-PURIN-6-AMINE'>8XA</scene>, <scene name='pdbligand=8XC:4-AMINO-1-(5-O-PHOSPHONO-BETA-D-XYLOFURANOSYL)PYRIMIDIN-2(1H)-ONE'>8XC</scene>, <scene name='pdbligand=8XG:2-AMINO-9-(5-O-PHOSPHONO-BETA-D-XYLOFURANOSYL)-1,9-DIHYDRO-6H-PURIN-6-ONE'>8XG</scene>, <scene name='pdbligand=8XU:1-(5-O-PHOSPHONO-BETA-D-XYLOFURANOSYL)PYRIMIDINE-2,4(1H,3H)-DIONE'>8XU</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n4j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n4j OCA], [https://pdbe.org/2n4j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n4j RCSB], [https://www.ebi.ac.uk/pdbsum/2n4j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n4j ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | There is a common interest for studying xeno-nucleic acid systems in the fields of synthetic biology and the origin of life, in particular, those with an engineered backbone and possessing novel properties. Along this line, we have investigated xylonucleic acid (XyloNA) containing a potentially prebiotic xylose sugar (a 3'-epimer of ribose) in its backbone. Herein, we report for the first time the synthesis of four XyloNA nucleotide building blocks and the assembly of XyloNA oligonucleotides containing all the natural nucleobases. A detailed investigation of pairing and structural properties of XyloNAs in comparison to DNA/RNA has been performed by thermal UV-melting, CD, and solution state NMR spectroscopic studies. XyloNA has been shown to be an orthogonal self-pairing system which adopts a slightly right-handed extended helical geometry. Our study on one hand, provides understanding for superior structure-function (-pairing) properties of DNA/RNA over XyloNA for selection as an informational polymer in the prebiotic context, while on the other hand, finds potential of XyloNA as an orthogonal genetic system for application in synthetic biology. | ||
| - | + | Xylonucleic acid: synthesis, structure, and orthogonal pairing properties.,Maiti M, Maiti M, Knies C, Dumbre S, Lescrinier E, Rosemeyer H, Ceulemans A, Herdewijn P Nucleic Acids Res. 2015 Jul 14. pii: gkv719. PMID:26175047<ref>PMID:26175047</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 2n4j" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Herdewijn P]] | ||
| + | [[Category: Lescrinier E]] | ||
| + | [[Category: Maiti M]] | ||
Current revision
Solution structure of a self complementary Xylonucleic Acid duplex
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