4zcf

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'''Unreleased structure'''
 
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The entry 4zcf is ON HOLD
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==Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I==
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<StructureSection load='4zcf' size='340' side='right'caption='[[4zcf]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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Authors: Gupta, Y.K., Chan, S-H., Xu, S-y., Aggarwal, A.K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4zcf]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZCF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZCF FirstGlance]. <br>
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Description: Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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[[Category: Xu, S-Y]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zcf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zcf OCA], [https://pdbe.org/4zcf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zcf RCSB], [https://www.ebi.ac.uk/pdbsum/4zcf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zcf ProSAT]</span></td></tr>
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[[Category: Chan, S-H]]
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</table>
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[[Category: Gupta, Y.K]]
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== Function ==
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[[Category: Aggarwal, A.K]]
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[https://www.uniprot.org/uniprot/T3RE_ECOLX T3RE_ECOLX] A type III restriction enzyme that recognizes 2 inversely oriented double-stranded sequences 5'-CAGCAG-3' and cleaves DNA 25-27 base pairs downstream of one site. DNA restriction requires both the Res and Mod subunits (PubMed:11178902, PubMed:15464603). DNA topology affects its action; relaxed and negatively supercoiled DNA are digested but positively supercoiled DNA is not a good substrate (PubMed:11178902). Interacts with DNA approximately one half-turn downstream of the recognition site (PubMed:26067164). After binding to one recognition site undergoes random one-dimensional diffusion along DNA until it collides with a stationary enzyme bound to the second DNA site, which is when DNA cleavage occurs (Probable).<ref>PMID:11178902</ref> <ref>PMID:15464603</ref> <ref>PMID:26067164</ref> <ref>PMID:26067164</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Aggarwal AK]]
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[[Category: Chan SH]]
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[[Category: Gupta YK]]
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[[Category: Xu SY]]

Current revision

Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I

PDB ID 4zcf

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