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4d1e

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==THE CRYSTAL STRUCTURE OF HUMAN MUSCLE ALPHA-ACTININ-2==
==THE CRYSTAL STRUCTURE OF HUMAN MUSCLE ALPHA-ACTININ-2==
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<StructureSection load='4d1e' size='340' side='right' caption='[[4d1e]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
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<StructureSection load='4d1e' size='340' side='right'caption='[[4d1e]], [[Resolution|resolution]] 3.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4d1e]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D1E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D1E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4d1e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D1E FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d1e OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d1e RCSB], [http://www.ebi.ac.uk/pdbsum/4d1e PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLZ:N-METHYL-LYSINE'>MLZ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d1e OCA], [https://pdbe.org/4d1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d1e RCSB], [https://www.ebi.ac.uk/pdbsum/4d1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d1e ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN]] Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:[http://omim.org/entry/612158 612158]]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:14567970</ref>
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[https://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN] Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:[https://omim.org/entry/612158 612158]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:14567970</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN]] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
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[https://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4d1e" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Actinin|Actinin]]
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*[[Actinin 3D structures|Actinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Djinovic-Carugo, K]]
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[[Category: Homo sapiens]]
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[[Category: Gkougkoulia, E]]
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[[Category: Large Structures]]
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[[Category: Pinotsis, N]]
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[[Category: Djinovic-Carugo K]]
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[[Category: Salmazo, A]]
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[[Category: Gkougkoulia E]]
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[[Category: Sjoeblom, B]]
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[[Category: Pinotsis N]]
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[[Category: Abd]]
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[[Category: Salmazo A]]
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[[Category: Actin binding domain]]
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[[Category: Sjoeblom B]]
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[[Category: Calmodulin-like domain]]
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[[Category: Contractile protein]]
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[[Category: Spectrin domain]]
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[[Category: Z-disc]]
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[[Category: Z-disk]]
[[Category: Z-disk]]

Current revision

THE CRYSTAL STRUCTURE OF HUMAN MUSCLE ALPHA-ACTININ-2

PDB ID 4d1e

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