5c4o
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Identification of a Novel Allosteric Binding Site for RORgt Inhibitors== | |
| - | + | <StructureSection load='5c4o' size='340' side='right'caption='[[5c4o]], [[Resolution|resolution]] 2.24Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5c4o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C4O FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.24Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4F1:4-{1-[2-CHLORO-6-(TRIFLUOROMETHYL)BENZOYL]-1H-INDAZOL-3-YL}BENZOIC+ACID'>4F1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c4o OCA], [https://pdbe.org/5c4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c4o RCSB], [https://www.ebi.ac.uk/pdbsum/5c4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c4o ProSAT]</span></td></tr> |
| - | [[Category: Parthasarathy | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Parthasarathy G]] | ||
| + | [[Category: Soisson S]] | ||
Current revision
Identification of a Novel Allosteric Binding Site for RORgt Inhibitors
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