3ldh

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[[Image:3ldh.gif|left|200px]]
 
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{{Structure
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==A comparison of the structures of apo dogfish m4 lactate dehydrogenase and its ternary complexes==
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|PDB= 3ldh |SIZE=350|CAPTION= <scene name='initialview01'>3ldh</scene>, resolution 3.0&Aring;
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<StructureSection load='3ldh' size='340' side='right'caption='[[3ldh]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene> and <scene name='pdbligand=PYR:PYRUVIC ACID'>PYR</scene>
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<table><tr><td colspan='2'>[[3ldh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Squalus_acanthias Squalus acanthias]. The June 2008 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Lactate Dehydrogenase'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2008_6 10.2210/rcsb_pdb/mom_2008_6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LDH FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/L-lactate_dehydrogenase L-lactate dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.27 1.1.1.27]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PYR:PYRUVIC+ACID'>PYR</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ldh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ldh OCA], [https://pdbe.org/3ldh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ldh RCSB], [https://www.ebi.ac.uk/pdbsum/3ldh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ldh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LDHA_SQUAC LDHA_SQUAC]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ld/3ldh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ldh ConSurf].
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<div style="clear:both"></div>
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'''A COMPARISON OF THE STRUCTURES OF APO DOGFISH M4 LACTATE DEHYDROGENASE AND ITS TERNARY COMPLEXES'''
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==See Also==
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*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3LDH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LDH OCA].
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[[Category: Lactate Dehydrogenase]]
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[[Category: Large Structures]]
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==Reference==
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[[Category: RCSB PDB Molecule of the Month]]
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A comparison of the structures of apo dogfish M4 lactate dehydrogenase and its ternary complexes., White JL, Hackert ML, Buehner M, Adams MJ, Ford GC, Lentz PJ Jr, Smiley IE, Steindel SJ, Rossmann MG, J Mol Biol. 1976 Apr 25;102(4):759-79. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/940154 940154]
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[[Category: Squalus acanthias]]
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[[Category: L-lactate dehydrogenase]]
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[[Category: Adams MJ]]
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[[Category: Single protein]]
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[[Category: Buehner M]]
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[[Category: Adams, M J.]]
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[[Category: Ford GC]]
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[[Category: Buehner, M.]]
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[[Category: Hackert ML]]
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[[Category: Ford, G C.]]
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[[Category: Lentzjunior PJ]]
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[[Category: Hackert, M L.]]
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[[Category: Rossmann MG]]
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[[Category: Lentzjunior, P J.]]
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[[Category: Smiley IE]]
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[[Category: Rossmann, M G.]]
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[[Category: Steindel SJ]]
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[[Category: Smiley, I E.]]
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[[Category: White JL]]
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[[Category: Steindel, S J.]]
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[[Category: White, J L.]]
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[[Category: ACE]]
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[[Category: NAD]]
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[[Category: PYR]]
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[[Category: choh donor]]
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[[Category: nad acceptr]]
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[[Category: oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 19:05:38 2008''
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Current revision

A comparison of the structures of apo dogfish m4 lactate dehydrogenase and its ternary complexes

PDB ID 3ldh

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