Hepatocyte growth factor activator

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(New page: <StructureSection load='2r0k' size='340' side='right' caption='Human hepatocyte growth factor activator complex with antibody light chain (PDB code 2r0k)' scene=''> '''Hepatocyte grow...)
Current revision (13:17, 15 May 2019) (edit) (undo)
 
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<StructureSection load='' size='350' side='right' caption='Human hepatocyte growth factor activator (magenta) complex with HGFA inhibitor type 1 (green) and phosphate (PDB code [[1yc0]])' scene='70/706236/Cv/1'>
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<StructureSection load='2r0k' size='340' side='right' caption='Human hepatocyte growth factor activator complex with antibody light chain (PDB code [[2r0k]])' scene=''>
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'''Hepatocyte growth factor activator''' (HGFA) is a serine protease which links tissue injury to activation of hepatocyte growth factor (HGF). HGFA converts HGF from its latent single-chain form to a heterodimeric active form. HGFA is synthesized as an inactive precursor which is converted to a heterodimer via proteolysis as a result of tissue injury.
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== Function ==
== Function ==
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'''Hepatocyte growth factor activator''' (HGFA) is a serine protease which links tissue injury to activation of hepatocyte growth factor (HGF). HGFA converts HGF from its latent single-chain form to a heterodimeric active form. HGFA is synthesized as an inactive precursor which is converted to a heterodimer via proteolysis as a result of tissue injury<ref>PMID:20402766</ref>.
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== Disease ==
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== Relevance ==
== Relevance ==
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Lower activity of HGFA results in impaired regeneration of damaged mucosal epithelium and may contribute to the progression of fibrotic lung cancer<ref>PMID:20142763</ref>.
== Structural highlights ==
== Structural highlights ==
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HGFA substrate binding cleft resembles other trypsin-like serine proteases with <scene name='70/706236/Cv/4'>inhibitors of the Kunitz type (α/β folds rich in Cys-Cys bonds)</scene> <ref>PMID:157134585</ref>.
</StructureSection>
</StructureSection>
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[[1ybw]] – hHGFA protease domain – human<BR />
[[1ybw]] – hHGFA protease domain – human<BR />
[[1yc0]] – hHGFA protease domain + Kunitz-type protease inhibitor<BR />
[[1yc0]] – hHGFA protease domain + Kunitz-type protease inhibitor<BR />
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[[2r0k]] – hHGFA protease domain + antibody light chain<BR />
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[[2r0l]], [[2r0k]], [[2wub]], [[2wuc]], [[3k2u]] – hHGFA protease domain + antibody <BR />
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[[2r0l]], [[2wub]], [[2wuc]], [[3k2u]] – hHGFA protease domain + antibody <BR />
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== References ==
== References ==
<references/>
<references/>
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[[Category:Topic Page]]

Current revision

Human hepatocyte growth factor activator (magenta) complex with HGFA inhibitor type 1 (green) and phosphate (PDB code 1yc0)

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3D Structures of hepatocyte growth factor activator

Updated on 15-May-2019

1ybw – hHGFA protease domain – human
1yc0 – hHGFA protease domain + Kunitz-type protease inhibitor
2r0l, 2r0k, 2wub, 2wuc, 3k2u – hHGFA protease domain + antibody

References

  1. ↑ Miyazawa K. Hepatocyte growth factor activator (HGFA): a serine protease that links tissue injury to activation of hepatocyte growth factor. FEBS J. 2010 May;277(10):2208-14. doi: 10.1111/j.1742-4658.2010.07637.x. Epub, 2010 Apr 2. PMID:20402766 doi:http://dx.doi.org/10.1111/j.1742-4658.2010.07637.x
  2. ↑ Wu KL, Li YQ, Tabassum A, Lu WY, Aubert I, Wong CS. Loss of neuronal protein expression in mouse hippocampus after irradiation. J Neuropathol Exp Neurol. 2010 Mar;69(3):272-80. doi:, 10.1097/NEN.0b013e3181d1afe4. PMID:20142763 doi:http://dx.doi.org/10.1097/NEN.0b013e3181d1afe4
  3. ↑ . PMID:157134585

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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