Neurophysin
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='Neurophysin-2 (green and cyan) complex with oxytocin (magenta and salmon) (PDB code [[1npo]])' scene='70/706270/Cv/1' pspeed='8'> |
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== Function == | == Function == | ||
| + | '''Neurophysins''' are carrier proteins which transport hormones from the hypothalamus to the posterior pituitary gland<ref>PMID:3147712</ref>. | ||
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| + | *'''Neurophysin-1''' transports oxytocin.<br /> | ||
| + | *'''Neurophysin-2''' transports vasopressin.<br /> | ||
| + | *'''Oxytocin''' is used to start labor and increase its speed.<br /> | ||
| + | *'''Vasopressin''' functions to retain water in the body and to constrict blood vessels. | ||
== Disease == | == Disease == | ||
| - | + | Mutations in neurophysin-2 are associated with familial diabetes<ref>PMID:7714110</ref>. | |
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== Structural highlights == | == Structural highlights == | ||
| + | <scene name='70/706270/Cv/4'>Neurophysin-2/oxytocin interactions</scene>. | ||
</StructureSection> | </StructureSection> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
| + | [[Category:Topic Page]] | ||
Current revision
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3D Structures of neurophysin
Updated on 23-July-2019
References
- ↑ Acher R, Chauvet J. Structure, processing and evolution of the neurohypophysial hormone-neurophysin precursors. Biochimie. 1988 Sep;70(9):1197-207. PMID:3147712
- ↑ Nagasaki H, Ito M, Yuasa H, Saito H, Fukase M, Hamada K, Ishikawa E, Katakami H, Oiso Y. Two novel mutations in the coding region for neurophysin-II associated with familial central diabetes insipidus. J Clin Endocrinol Metab. 1995 Apr;80(4):1352-6. PMID:7714110 doi:http://dx.doi.org/10.1210/jcem.80.4.7714110
