4zjh
From Proteopedia
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==Crystal structure of native alpha-2-macroglobulin from Escherichia coli spanning domains NIE-MG1.== | ==Crystal structure of native alpha-2-macroglobulin from Escherichia coli spanning domains NIE-MG1.== | ||
| - | <StructureSection load='4zjh' size='340' side='right' caption='[[4zjh]], [[Resolution|resolution]] 1.60Å' scene=''> | + | <StructureSection load='4zjh' size='340' side='right'caption='[[4zjh]], [[Resolution|resolution]] 1.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4zjh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJH OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4zjh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZJH FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zjh OCA], [https://pdbe.org/4zjh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zjh RCSB], [https://www.ebi.ac.uk/pdbsum/4zjh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zjh ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A2MG_ECOLI A2MG_ECOLI] Protects the bacterial cell from host peptidases (PubMed:18697741, PubMed:26143919, PubMed:26100869). Acts by a 'trapping' mechanism. Cleavage of the bait-region domain by host peptidases leads to a global conformational change, which results in entrapment of the host peptidase and activation of the thioester bond that covalently binds the attacking host peptidase (PubMed:26143919, PubMed:26100869). Trapped peptidases are still active except against very large substrates (PubMed:26100869). May protect the entire periplam, including the lipoproteins anchored to the periplasmic side of the outer membrane, against intruding endopeptidases (PubMed:26100869).<ref>PMID:18697741</ref> <ref>PMID:26100869</ref> <ref>PMID:26143919</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4zjh" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Arede | + | [[Category: Escherichia coli K-12]] |
| - | [[Category: Caston | + | [[Category: Large Structures]] |
| - | [[Category: Duquerroy | + | [[Category: Arede P]] |
| - | [[Category: Garcia-Ferrer | + | [[Category: Caston JR]] |
| - | [[Category: Gomez-Blanco | + | [[Category: Duquerroy S]] |
| - | [[Category: Gomis-Ruth | + | [[Category: Garcia-Ferrer I]] |
| - | [[Category: Goulas | + | [[Category: Gomez-Blanco J]] |
| - | [[Category: Luque | + | [[Category: Gomis-Ruth XF]] |
| - | + | [[Category: Goulas T]] | |
| - | + | [[Category: Luque D]] | |
Current revision
Crystal structure of native alpha-2-macroglobulin from Escherichia coli spanning domains NIE-MG1.
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