5cbx
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5cbx is ON HOLD Authors: Hudson, W.H., Ortlund, E.A. Description: Category: Unreleased Structures Category: Hudson, W.H [[Category: Ortlun...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==AncGR DNA Binding Domain - (+)GRE Complex== | |
| + | <StructureSection load='5cbx' size='340' side='right'caption='[[5cbx]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5cbx]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5CBX FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5cbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cbx OCA], [https://pdbe.org/5cbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5cbx RCSB], [https://www.ebi.ac.uk/pdbsum/5cbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5cbx ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:[https://omim.org/entry/138040 138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.<ref>PMID:12050230</ref> <ref>PMID:1704018</ref> <ref>PMID:7683692</ref> <ref>PMID:11589680</ref> <ref>PMID:11701741</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GCR_HUMAN GCR_HUMAN] Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation.<ref>PMID:21664385</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Glucocorticoid receptor 3D structures|Glucocorticoid receptor 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Hudson | + | __TOC__ |
| - | [[Category: Ortlund | + | </StructureSection> |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Unidentified]] | ||
| + | [[Category: Hudson WH]] | ||
| + | [[Category: Ortlund EA]] | ||
Current revision
AncGR DNA Binding Domain - (+)GRE Complex
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