This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


TIR domain-containing adapter protein

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:06, 25 April 2022) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
<StructureSection load='3ub2' size='340' side='right' caption='MAL adaptor protein TIR domain complex with dithiothreitol (PDB code [[3ub2]])' scene=''>
<StructureSection load='3ub2' size='340' side='right' caption='MAL adaptor protein TIR domain complex with dithiothreitol (PDB code [[3ub2]])' scene=''>
-
'''TIR domain-containing adaptor protein''' (TIRAP) is one of 5 proteins involved in the Toll interleukin 1 receptor signaling pathway of the immune system. The 5 adaptor proteins are: '''MyD88, MAL, TRIF, TRAM and SARM'''. The TIR domain, which is found in Toll-like receptors and in adaptor proteins. The domain containing 135 to 160 amino acids, consists of 3 boxes of conserved residues. The TIR domain is involved in the interaction between Toll-like receptors and the adaptor protein. TIRAP activates NF-kB, MAPK1, MAPK3 and JNK which results in the inflammatory response.
+
'''TIR domain-containing adapter protein''' or '''Toll/Interleukin-1 receptor domain-containing adapter protein''' (TIRAP) is one of 5 proteins involved in the Toll interleukin 1 receptor signaling pathway of the immune system. The 5 adaptor proteins are: '''MyD88, MAL, TRIF, TRAM and SARM'''. The TIR domain is found in Toll-like receptors and in adaptor proteins. The domain containing 135 to 160 amino acids, consists of 3 boxes of conserved residues. The TIR domain is involved in the interaction between Toll-like receptors and the adaptor protein<ref>PMID:17457343</ref>. TIRAP activates NF-kB, MAPK1, MAPK3 and JNK which results in the inflammatory response.
-
 
+
-
== Function ==
+
-
<scene name='70/706257/Cv/3'>TextToBeDisplayed</scene>
+
-
== Disease ==
+
-
 
+
-
== Relevance ==
+
-
 
+
-
== Structural highlights ==
+
</StructureSection>
</StructureSection>
-
== 3D Structures of TIR domain-containing adaptor protein ==
+
== 3D Structures of TIR domain-containing adapter protein ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
-
*MAL
+
*TIRAP or Toll/interleukin-1 receptor domain-containing adapter protein or MAL
-
**[[2y92]], [[3ub2]] – hMAL TIR domain - human<br />
+
**[[2y92]], [[3ub2]], [[4fz5]], [[4lqd]] – hTIRAP TIR domain 81-221 - human<br />
 +
**[[5uzb]] – hMAL TIR domain - Cryo EM<br />
**[[3ub3]], [[3ub4]] – hMAL TIR domain (mutant)<br />
**[[3ub3]], [[3ub4]] – hMAL TIR domain (mutant)<br />
 +
**[[2m1w]], [[2m1x]], [[2ndh]] – hMAL TIR domain (mutant) - NMR<br />
 +
**[[2m63]] – hMAL N-terminal domain - NMR<br />
 +
**[[5t7q]] – hMAL residues 15-35 - NMR<br />
 +
 +
*MyD88 or myeloid differentiation primary response protein MyD88; Domains – death 12-163; TIR 157-296
 +
 +
**[[4dom]], [[4eo7]], [[7beq]], [[7ber]], [[7l6w]] – hMyD88 TIR domain 157-296<br />
 +
**[[2z5v]] – hMyD88 TIR domain - NMR<br />
 +
**[[6i3n]] – hMyD88 death domain – Cryo EM<br />
 +
**[[3mop]] – hMyD88 death domain + IRAK-2 + IRAK-4<br />
 +
 +
*TRIF
 +
 +
 +
**[[4c0m]] – hTRIF N-terminal domain <br />
 +
**[[4bsx]] – hTRIF N-terminal domain (mutant)<br />
 +
 +
*TcpB
-
*MyD88
+
**[[4lqc]], [[4c7m]] – TcpB TIR domain (mutant) – ''Brucella melitensis''<br />
-
**[[4fz5]], [[4lqd]] – hMyD88 TIR domain <br />
 
}}
}}
== References ==
== References ==
<references/>
<references/>
 +
[[Category:Topic Page]]

Current revision

MAL adaptor protein TIR domain complex with dithiothreitol (PDB code 3ub2)

Drag the structure with the mouse to rotate

3D Structures of TIR domain-containing adapter protein

Updated on 25-April-2022


References

  1. ↑ O'Neill LA, Bowie AG. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol. 2007 May;7(5):353-64. PMID:17457343 doi:http://dx.doi.org/nri2079

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/TIR_domain-containing_adapter_protein"
Personal tools