4d76

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:50, 14 September 2022) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 4d76 is ON HOLD until Paper Publication
+
==Human FXIa in complex with small molecule inhibitors.==
 +
<StructureSection load='4d76' size='340' side='right'caption='[[4d76]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[4d76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D76 FirstGlance]. <br>
 +
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=J1J:N-[(2S)-1-({5-[(DIAMINOMETHYLIDENE)AMINO]PENTYL}AMINO)-1-OXO-3-PHENYLPROPAN-2-YL]-4-HYDROXY-2-OXO-1,2-DIHYDROQUINOLINE-6-CARBOXAMIDE'>J1J</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d76 OCA], [https://pdbe.org/4d76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d76 RCSB], [https://www.ebi.ac.uk/pdbsum/4d76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d76 ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[[https://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Defects in F11 are the cause of factor XI deficiency (FA11D) [MIM:[https://omim.org/entry/612416 612416]]; also known as plasma thromboplastin antecedent deficiency or Rosenthal syndrome. It is a hemorrhagic disease characterized by reduced levels and activity of factor XI resulting in moderate bleeding symptoms, usually occurring after trauma or surgery. Patients usually do not present spontaneous bleeding but women can present with menorrhagia. Hemorrhages are usually moderate.<ref>PMID:2813350</ref> <ref>PMID:1547342</ref> <ref>PMID:7888672</ref> <ref>PMID:7669672</ref> <ref>PMID:9401068</ref> <ref>PMID:9787168</ref> <ref>PMID:10027710</ref> <ref>PMID:10606881</ref> <ref>PMID:11895778</ref> <ref>PMID:15026311</ref> <ref>PMID:15180874</ref> <ref>PMID:15953011</ref> <ref>PMID:16607084</ref> <ref>PMID:18005151</ref> <ref>PMID:21668437</ref> <ref>PMID:21457405</ref> <ref>PMID:22016685</ref> <ref>PMID:22322133</ref> <ref>PMID:21999818</ref> <ref>PMID:22159456</ref>
 +
== Function ==
 +
[[https://www.uniprot.org/uniprot/FA11_HUMAN FA11_HUMAN]] Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX.
-
Authors: Sandmark, J., Oster, L., Jacso, T., Ullah, V., Redzick, A., Borjesson, U., Olsson, T., Norberg, M., Akerud, T.
+
==See Also==
-
 
+
*[[Factor XIa|Factor XIa]]
-
Description: Human FXIa in complex with small molecule inhibitors.
+
== References ==
-
[[Category: Unreleased Structures]]
+
<references/>
-
[[Category: Norberg, M]]
+
__TOC__
-
[[Category: Redzick, A]]
+
</StructureSection>
-
[[Category: Oster, L]]
+
[[Category: Homo sapiens]]
-
[[Category: Ullah, V]]
+
[[Category: Large Structures]]
-
[[Category: Olsson, T]]
+
[[Category: Akerud T]]
-
[[Category: Akerud, T]]
+
[[Category: Borjesson U]]
-
[[Category: Borjesson, U]]
+
[[Category: Jacso T]]
-
[[Category: Sandmark, J]]
+
[[Category: Norberg M]]
-
[[Category: Jacso, T]]
+
[[Category: Olsson T]]
 +
[[Category: Oster L]]
 +
[[Category: Redzick A]]
 +
[[Category: Sandmark J]]
 +
[[Category: Ullah V]]

Current revision

Human FXIa in complex with small molecule inhibitors.

PDB ID 4d76

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4d76"
Personal tools