5c6h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:08, 20 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5c6h is ON HOLD until sometime in the future
+
==Mcl-1 complexed with Mule==
 +
<StructureSection load='5c6h' size='340' side='right'caption='[[5c6h]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[5c6h]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C6H FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c6h OCA], [https://pdbe.org/5c6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c6h RCSB], [https://www.ebi.ac.uk/pdbsum/5c6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c6h ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN] Defects in HUWE1 are the cause of mental retardation syndromic X-linked Turner type (MRXST) [MIM:[https://omim.org/entry/300706 300706]; also known as mental retardation and macrocephaly syndrome. MRXST shows clinical variability. Associated phenotypes include macrocephaly and variable contractures. A chromosomal microduplication involving HUWE1 and HSD17B10 is the cause of mental retardation X-linked type 17 (MRX17) [MIM:[https://omim.org/entry/300705 300705]; also known as mental retardation X-linked type 31 (MRX31). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. In contrast to syndromic or specific X-linked mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation.<ref>PMID:18252223</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/HUWE1_HUMAN HUWE1_HUMAN] E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.<ref>PMID:15989956</ref> <ref>PMID:15989957</ref> <ref>PMID:15767685</ref> <ref>PMID:15567145</ref> <ref>PMID:17567951</ref> <ref>PMID:18488021</ref> <ref>PMID:19713937</ref>
-
Authors: Song, T., Wang, Z., Ji, F., Chai, G., Liu, Y., Li, X., Li, Z., Fan, Y., Zhang, Z.
+
==See Also==
-
 
+
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
-
Description: Mcl-1 complexed with Mule
+
== References ==
-
[[Category: Unreleased Structures]]
+
<references/>
-
[[Category: Song, T]]
+
__TOC__
-
[[Category: Zhang, Z]]
+
</StructureSection>
-
[[Category: Fan, Y]]
+
[[Category: Homo sapiens]]
-
[[Category: Ji, F]]
+
[[Category: Large Structures]]
-
[[Category: Liu, Y]]
+
[[Category: Chai G]]
-
[[Category: Wang, Z]]
+
[[Category: Fan Y]]
-
[[Category: Chai, G]]
+
[[Category: Ji F]]
-
[[Category: Li, X]]
+
[[Category: Li X]]
-
[[Category: Li, Z]]
+
[[Category: Li Z]]
 +
[[Category: Liu Y]]
 +
[[Category: Song T]]
 +
[[Category: Wang Z]]
 +
[[Category: Zhang Z]]

Current revision

Mcl-1 complexed with Mule

PDB ID 5c6h

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5c6h"
Personal tools